Responses of Airway Epithelium to Environmental Injury : Role in the Induction Phase of Childhood Asthma
Joint Authors
Herbert, Cristan
Kaiko, Gerard E.
Mattes, Joerg E.
Kumar, Rakesh K.
Siegle, Jessica S.
Foster, Paul S.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-11-01
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The pathogenesis of allergic asthma in childhood remains poorly understood.
Environmental factors which appear to contribute to allergic sensitisation, with development of a Th2-biased immunological response in genetically predisposed individuals, include wheezing lower respiratory viral infections in early life and exposure to airborne environmental pollutants.
These may activate pattern recognition receptors and/or cause oxidant injury to airway epithelial cells (AECs).
In turn, this may promote Th2 polarisation via a “final common pathway” involving interaction between AEC, dendritic cells, and CD4+ T lymphocytes.
Potentially important cytokines produced by AEC include thymic stromal lymphopoietin and interleukin-25.
Their role is supported by in vitro studies using human AEC, as well as by experiments in animal models.
To date, however, few investigations have employed models of the induction phase of childhood asthma.
Further research may help to identify interventions that could reduce the risk of allergic asthma.
American Psychological Association (APA)
Kumar, Rakesh K.& Siegle, Jessica S.& Kaiko, Gerard E.& Herbert, Cristan& Mattes, Joerg E.& Foster, Paul S.. 2011. Responses of Airway Epithelium to Environmental Injury : Role in the Induction Phase of Childhood Asthma. Journal of Allergy،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-457922
Modern Language Association (MLA)
Kumar, Rakesh K.…[et al.]. Responses of Airway Epithelium to Environmental Injury : Role in the Induction Phase of Childhood Asthma. Journal of Allergy No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-457922
American Medical Association (AMA)
Kumar, Rakesh K.& Siegle, Jessica S.& Kaiko, Gerard E.& Herbert, Cristan& Mattes, Joerg E.& Foster, Paul S.. Responses of Airway Epithelium to Environmental Injury : Role in the Induction Phase of Childhood Asthma. Journal of Allergy. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-457922
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-457922