Expression of Nuclear Factor Kappa B and Survivin in Psoriasis

Abstract EN

Background and Objective.

Suppression of apoptosis has been proposed as a mechanism responsible for epidermal thickness in psoriasis.

Survivin is a member of the inhibitor of apoptosis family.

Nuclear factor kappa B (NF-κB) is one of the transcriptional factors that regulate many genes affecting apoptosis.

The aim of this study was to determine survivin and NF-κB expressions in psoriasis in comparison with normal epidermis.

Patients and Methods.

Immunohistochemical expressions of survivin and NF-κB were investigated in 41 psoriatic and 21 normal skin samples.

Results.

Diffuse nuclear survivin expression in all epidermal layers was seen in all of the psoriatic samples.

NF-κB expression in different epidermal locations was seen in all of the psoriatic samples.

Nuclear staining was positive in 40 psoriasis samples.

Similar survivin and NF-κB expressions were observed in normal skin samples.

Conclusion.

Since similar expressions are seen in both normal and psoriatic epidermis, no important roles for survivin and NF-κB can be attributed in epidermal proliferation and thickness seen in psoriasis.