Occurrence and Impact of Minor Histocompatibility Antigens' Disparities on Outcomes of Hematopoietic Stem Cell Transplantation from HLA-Matched Sibling Donors
Joint Authors
Markiewicz, Miroslaw
Kyrcz-Krzemien, Slawomira
Dzierzak-Mietla, Monika
Koclega, Anna
Zielinska, Patrycja
Sobczyk Kruszelnicka, Malgorzata
Sylwia, Mizia
Siekiera, Urszula
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-11-08
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
We have examined the alleles of eleven minor histocompatibility antigens (MiHAs) and investigated the occurrence of immunogenic MiHA disparities in 62 recipients of allogeneic hematopoietic cell transplantation (allo-HCT) with myeloablative conditioning performed between 2000 and 2008 and in their HLA-matched sibling donors.
Immunogenic MiHA mismatches were detected in 42 donor-recipient pairs: in 29% MiHA was mismatched in HVG direction, in another 29% in GVH direction; bidirectional MiHA disparity was detected in 10% and no MiHA mismatches in 32%.
Patients with GVH-directed HY mismatches had lower both overall survival and disease-free survival at 3 years than patients with compatible HY; also higher incidence of both severe acute GvHD and extensive chronic GVHD was observed in patients with GVH-directed HY mismatch.
On contrary, GVH-directed mismatches of autosomally encoded MiHAs had no negative effect on overall survival.
Results of our study help to understand why posttransplant courses of allo-HCT from siblings may vary despite the complete high-resolution HLA matching of a donor and a recipient.
American Psychological Association (APA)
Dzierzak-Mietla, Monika& Markiewicz, Miroslaw& Siekiera, Urszula& Sylwia, Mizia& Koclega, Anna& Zielinska, Patrycja…[et al.]. 2012. Occurrence and Impact of Minor Histocompatibility Antigens' Disparities on Outcomes of Hematopoietic Stem Cell Transplantation from HLA-Matched Sibling Donors. Bone Marrow Research،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-457933
Modern Language Association (MLA)
Dzierzak-Mietla, Monika…[et al.]. Occurrence and Impact of Minor Histocompatibility Antigens' Disparities on Outcomes of Hematopoietic Stem Cell Transplantation from HLA-Matched Sibling Donors. Bone Marrow Research No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-457933
American Medical Association (AMA)
Dzierzak-Mietla, Monika& Markiewicz, Miroslaw& Siekiera, Urszula& Sylwia, Mizia& Koclega, Anna& Zielinska, Patrycja…[et al.]. Occurrence and Impact of Minor Histocompatibility Antigens' Disparities on Outcomes of Hematopoietic Stem Cell Transplantation from HLA-Matched Sibling Donors. Bone Marrow Research. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-457933
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-457933