![](/images/graphics-bg.png)
DNA Damage and Base Excision Repair in Mitochondria and Their Role in Aging
Author
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-12-30
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Pharmacy, Health & Medical Sciences
Abstract EN
During the last decades, our knowledge about the processes involved in the aging process has exponentially increased.
However, further investigation will be still required to globally understand the complexity of aging.
Aging is a multifactorial phenomenon characterized by increased susceptibility to cellular loss and functional decline, where mitochondrial DNA mutations and mitochondrial DNA damage response are thought to play important roles.
Due to the proximity of mitochondrial DNA to the main sites of mitochondrial-free radical generation, oxidative stress is a major source of mitochondrial DNA mutations.
Mitochondrial DNA repair mechanisms, in particular the base excision repair pathway, constitute an important mechanism for maintenance of mitochondrial DNA integrity.
The results reviewed here support that mitochondrial DNA damage plays an important role in aging.
American Psychological Association (APA)
Gredilla, Ricardo. 2010. DNA Damage and Base Excision Repair in Mitochondria and Their Role in Aging. Journal of Aging Research،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-457934
Modern Language Association (MLA)
Gredilla, Ricardo. DNA Damage and Base Excision Repair in Mitochondria and Their Role in Aging. Journal of Aging Research No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-457934
American Medical Association (AMA)
Gredilla, Ricardo. DNA Damage and Base Excision Repair in Mitochondria and Their Role in Aging. Journal of Aging Research. 2010. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-457934
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-457934