Aqueous Concentrations of Vascular Endothelial Growth Factor in Eyes with High Myopia with and without Choroidal Neovascularization
Joint Authors
Wakabayashi, Taku
Ikuno, Yasushi
Nishida, Kohji
Hamasaki, Toshimitsu
Oshima, Yusuke
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-03-06
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Purpose.
To investigate aqueous concentrations of vascular endothelial growth factor (VEGF) in eyes with myopic choroidal neovascularization (CNV).
Methods.
Aqueous samples were collected, and VEGF concentrations were measured by enzyme-linked immunosorbent assay in 16 eyes (16 patients) with active myopic CNV, 23 eyes (16 patients) with high myopia without myopic CNV, and 8 control eyes (7 patients).
Differences in the concentrations of VEGF in each group were compared.
Results.
The estimated mean VEGF concentrations were significantly lower in eyes with myopic CNV (82.0 pg/mL) (P=0.016 ) and with high myopia without myopic CNV (58.9 pg/mL) (P<0.001) compared with controls (116.6 pg/mL).
The estimated mean VEGF concentration was significantly (P<0.05) higher in eyes with myopic CNV than in those without myopic CNV in highly myopic eyes.
In eyes with high myopia with and without CNV, the VEGF concentration was significantly (stepwise regression analysis, R=0.325, P=0.044) associated with the presence of myopic CNV but not with age, axial length, or intraocular pressure.
Conclusion.
Increased levels of VEGF may play a role in the pathogenesis of CNV in highly myopic eyes.
American Psychological Association (APA)
Wakabayashi, Taku& Ikuno, Yasushi& Oshima, Yusuke& Hamasaki, Toshimitsu& Nishida, Kohji. 2013. Aqueous Concentrations of Vascular Endothelial Growth Factor in Eyes with High Myopia with and without Choroidal Neovascularization. Journal of Ophthalmology،Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-457960
Modern Language Association (MLA)
Wakabayashi, Taku…[et al.]. Aqueous Concentrations of Vascular Endothelial Growth Factor in Eyes with High Myopia with and without Choroidal Neovascularization. Journal of Ophthalmology No. 2013 (2013), pp.1-5.
https://search.emarefa.net/detail/BIM-457960
American Medical Association (AMA)
Wakabayashi, Taku& Ikuno, Yasushi& Oshima, Yusuke& Hamasaki, Toshimitsu& Nishida, Kohji. Aqueous Concentrations of Vascular Endothelial Growth Factor in Eyes with High Myopia with and without Choroidal Neovascularization. Journal of Ophthalmology. 2013. Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-457960
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-457960