Repertoire of Protein Kinases Encoded in the Genome of Takifugu rubripes
Joint Authors
Srinivasan, N.
Tyagi, N.
Anamika, K.
Yamunadevi, S.
Rakshambikai, R.
Source
Comparative and Functional Genomics
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-14
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Takifugu rubripes is teleost fish widely used in comparative genomics to understand the human system better due to its similarities both in number of genes and structure of genes.
In this work we survey the fugu genome, and, using sensitive computational approaches, we identify the repertoire of putative protein kinases and classify them into groups and subfamilies.
The fugu genome encodes 519 protein kinase-like sequences and this number of putative protein kinases is comparable closely to that of human.
However, in spite of its similarities to human kinases at the group level, there are differences at the subfamily level as noted in the case of KIS and DYRK subfamilies which contribute to differences which are specific to the adaptation of the organism.
Also, certain unique domain combination of galectin domain and YkA domain suggests alternate mechanisms for immune response and binding to lipoproteins.
Lastly, an overall similarity with the MAPK pathway of humans suggests its importance to understand signaling mechanisms in humans.
Overall the fugu serves as a good model organism to understand roles of human kinases as far as kinases such as LRRK and IRAK and their associated pathways are concerned.
American Psychological Association (APA)
Rakshambikai, R.& Yamunadevi, S.& Anamika, K.& Tyagi, N.& Srinivasan, N.. 2012. Repertoire of Protein Kinases Encoded in the Genome of Takifugu rubripes. Comparative and Functional Genomics،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-458062
Modern Language Association (MLA)
Rakshambikai, R.…[et al.]. Repertoire of Protein Kinases Encoded in the Genome of Takifugu rubripes. Comparative and Functional Genomics No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-458062
American Medical Association (AMA)
Rakshambikai, R.& Yamunadevi, S.& Anamika, K.& Tyagi, N.& Srinivasan, N.. Repertoire of Protein Kinases Encoded in the Genome of Takifugu rubripes. Comparative and Functional Genomics. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-458062
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-458062