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Assessment of the Immune Responses Induced in Cattle after Inoculation of a Mycobacterium bovis Strain Deleted in Two mce2 Genes
Joint Authors
Cataldi, Angel Adrián
Blanco, Federico Carlos
Gravisaco, María José
Garbaccio, Sergio
Vagnoni, Lucas
Bigi, Fabiana
Meikle, Virginia
Soria, Marcelo
Bianco, María Verónica
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-05
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The generation of efficient candidate vaccines against bovine tuberculosis will contribute to the control of this zoonotic disease.
Rationally attenuated Mycobacterium bovis strains generated by knockout of virulence genes are promising candidate vaccines.
However, to be effective, these candidate vaccines should at least maintain the immunological properties of their virulent parental M.
bovis strains.
Therefore, the aim of this study was to obtain an M.
bovis strain deleted in the mce2 genes and evaluate the effect of the mutation on the immunological profile elicited by the bacteria in cattle.
We showed that the activation of CD4+ T cells in cattle inoculated with the mutant strain was equivalent to that in animals inoculated with the parental strain.
Moreover, after in vitro stimulation, peripheral blood mononuclear cells from animals inoculated with the mutant produced higher levels of mRNA Th-1 cytokines than the parental strain.
Therefore, these results indicate that the mce2 mutant is a promising candidate vaccine against bovine tuberculosis.
American Psychological Association (APA)
Blanco, Federico Carlos& Soria, Marcelo& Gravisaco, María José& Bianco, María Verónica& Meikle, Virginia& Garbaccio, Sergio…[et al.]. 2012. Assessment of the Immune Responses Induced in Cattle after Inoculation of a Mycobacterium bovis Strain Deleted in Two mce2 Genes. Journal of Biomedicine and Biotechnology،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-458070
Modern Language Association (MLA)
Blanco, Federico Carlos…[et al.]. Assessment of the Immune Responses Induced in Cattle after Inoculation of a Mycobacterium bovis Strain Deleted in Two mce2 Genes. Journal of Biomedicine and Biotechnology No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-458070
American Medical Association (AMA)
Blanco, Federico Carlos& Soria, Marcelo& Gravisaco, María José& Bianco, María Verónica& Meikle, Virginia& Garbaccio, Sergio…[et al.]. Assessment of the Immune Responses Induced in Cattle after Inoculation of a Mycobacterium bovis Strain Deleted in Two mce2 Genes. Journal of Biomedicine and Biotechnology. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-458070
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-458070