ADAM23, a Gene Related to LGI1, Is Not Linked to Autosomal Dominant Lateral Temporal Epilepsy
Joint Authors
Striano, Salvatore
Boniver, Clementina
Busolin, Giorgia
Binelli, Simona
Mecarelli, Oriano
de Falco, Fabrizio
Vettori, Andrea
Gambardella, Antonio
Santulli, Lia
Nobile, Carlo
Banfi, Paola
Michelucci, Roberto
Vianello Dri, Valeria
Rigon, Laura
la Neve, Angela
Pasini, Elena
Giallonardo, Anna T.
Egeo, Gabriella
Striano, Pasquale
Pulitano, Patrizia
Di Bonaventura, Carlo
Source
Epilepsy Research and Treatment
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-12-21
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Autosomal dominant lateral temporal epilepsy (ADTLE) is an inherited epileptic syndrome characterized by ictal auditory symptoms or aphasia, negative MRI findings, and relatively benign evolution.
Mutations responsible for ADLTE have been found in the LGI1 gene.
The functions of the Lgi1 protein apparently are mediated by interactions with members of the ADAM protein family: it binds the postsynaptic receptor ADAM22 to regulate glutamate-AMPA currents at excitatory synapses and also the ADAM23 receptor to promote neurite outgrowth in vitro and dendritic arborization in vivo.
Because alteration of each of these neuronal mechanisms may underlie ADLTE, ADAM22 and ADAM23 are candidate genes for this syndrome.
In a previous work, we excluded a major role of ADAM22 in the aetiology of ADLTE.
Here, we performed linkage analysis between microsatellite markers within or flanking the ADAM23 gene and ADLTE in 13 Italian families.
The results exclude ADAM23 as major causative gene for ADLTE.
American Psychological Association (APA)
Rigon, Laura& Vettori, Andrea& Busolin, Giorgia& Egeo, Gabriella& Pulitano, Patrizia& Santulli, Lia…[et al.]. 2010. ADAM23, a Gene Related to LGI1, Is Not Linked to Autosomal Dominant Lateral Temporal Epilepsy. Epilepsy Research and Treatment،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-458072
Modern Language Association (MLA)
Rigon, Laura…[et al.]. ADAM23, a Gene Related to LGI1, Is Not Linked to Autosomal Dominant Lateral Temporal Epilepsy. Epilepsy Research and Treatment No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-458072
American Medical Association (AMA)
Rigon, Laura& Vettori, Andrea& Busolin, Giorgia& Egeo, Gabriella& Pulitano, Patrizia& Santulli, Lia…[et al.]. ADAM23, a Gene Related to LGI1, Is Not Linked to Autosomal Dominant Lateral Temporal Epilepsy. Epilepsy Research and Treatment. 2010. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-458072
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-458072