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Optimization of Extraction and Enrichment of Steroidal Alkaloids from Bulbs of Cultivated Fritillaria cirrhosa
Joint Authors
Jiang, Jinghui
Wang, Xiaoxia
Wang, Dongdong
Wang, Shu
Wang, Nanyi
Du, Qingdan
Liu, Simei
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-01
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
The bulbs of cultivated Fritillaria cirrhosa (BCFC) are used in China both for food and folk medicine due to its powerful biological activities.
The aim of this study is to optimize the extraction and enrichment conditions of alkaloids from BCFC.
Firstly, the orthogonal experimental design was used to optimize and evaluate four variables (ethanol concentration, solid-liquid ratio, extraction time, and temperature).
Thereafter, resin adsorption was as a means to enrich alkaloids.
Among 16 tested resins, H-103 resin presented higher adsorption capacity and desorption ratio.
The equilibrium experimental data of the adsorption of total alkaloids, imperialine, and peimisine were well-fitted to the pseudo-first-order kinetics model, Langmuir and Freundlich isotherms models.
Finally, in order to optimize the parameters for purifying alkaloids, dynamic adsorption and desorption tests were carried out.
After one run treatment with H-103 resin, the contents of total alkaloids, imperialine, and peimisine in the product were 21.40-, 18.31-, and 22.88-fold increased with recovery yields of 94.43%, 90.57%, and 96.16%, respectively.
American Psychological Association (APA)
Wang, Dongdong& Wang, Shu& Du, Qingdan& Wang, Nanyi& Liu, Simei& Wang, Xiaoxia…[et al.]. 2014. Optimization of Extraction and Enrichment of Steroidal Alkaloids from Bulbs of Cultivated Fritillaria cirrhosa. BioMed Research International،Vol. 2014, no. 2014, pp.1-15.
https://search.emarefa.net/detail/BIM-458081
Modern Language Association (MLA)
Wang, Dongdong…[et al.]. Optimization of Extraction and Enrichment of Steroidal Alkaloids from Bulbs of Cultivated Fritillaria cirrhosa. BioMed Research International No. 2014 (2014), pp.1-15.
https://search.emarefa.net/detail/BIM-458081
American Medical Association (AMA)
Wang, Dongdong& Wang, Shu& Du, Qingdan& Wang, Nanyi& Liu, Simei& Wang, Xiaoxia…[et al.]. Optimization of Extraction and Enrichment of Steroidal Alkaloids from Bulbs of Cultivated Fritillaria cirrhosa. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-15.
https://search.emarefa.net/detail/BIM-458081
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-458081