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BlueBerry Isolate, Pterostilbene, Functions as a Potential Anticancer Stem Cell Agent in Suppressing Irradiation-Mediated Enrichment of Hepatoma Stem Cells
Joint Authors
Chiou, Jeng-Fong
Yeh, Chi-Tai
Lee, Chi-Ming
Lin, Yen-Kuang
Hsiao, Michael
Su, Yen-Hao
Lin, Yuh-Feng
Wu, Alexander T. H.
Lee, Wei-Hwa
Wu, Chih-Hsiung
Huynh, Thanh-Tuan
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-26
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
For many malignancies, radiation therapy remains the second option only to surgery in terms of its curative potential.
However, radiation-induced tumor cell death is limited by a number of factors, including the adverse response of the tumor microenvironment to the treatment and either intrinsic or acquired mechanisms of evasive resistance, and the existence of cancer stem cells (CSCs).
In this study, we demonstrated that using different doses of irradiation led to the enrichment of CD133+ Mahlavu cells using flow cytometric method.
Subsequently, CD133+ Mahlavu cells enriched by irradiation were characterized for their stemness gene expression, self-renewal, migration/invasion abilities, and radiation resistance.
Having established irradiation-enriched CD133+ Mahlavu cells with CSC properties, we evaluated a phytochemical, pterostilbene (PT), found abundantly in blueberries, against irradiation-enriched CSCs.
It was shown that PT treatment dose-dependently reduced the enrichment of CD133+ Mahlavu cells upon irradiation; PT treatment also prevented tumor sphere formation, reduced stemness gene expression, and suppressed invasion and migration abilities as well as increasing apoptosis of CD133+ Mahlavu CSCs.
Based on our experimental data, pterostilbene could be used to prevent the enrichment of CD133+ hepatoma CSCs and should be considered for future clinical testing as a combined agent for HCC patients.
American Psychological Association (APA)
Lin, Yen-Kuang& Hsiao, Michael& Wu, Chih-Hsiung& Lin, Yuh-Feng& Wu, Alexander T. H.& Yeh, Chi-Tai…[et al.]. 2013. BlueBerry Isolate, Pterostilbene, Functions as a Potential Anticancer Stem Cell Agent in Suppressing Irradiation-Mediated Enrichment of Hepatoma Stem Cells. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-458085
Modern Language Association (MLA)
Lin, Yen-Kuang…[et al.]. BlueBerry Isolate, Pterostilbene, Functions as a Potential Anticancer Stem Cell Agent in Suppressing Irradiation-Mediated Enrichment of Hepatoma Stem Cells. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-458085
American Medical Association (AMA)
Lin, Yen-Kuang& Hsiao, Michael& Wu, Chih-Hsiung& Lin, Yuh-Feng& Wu, Alexander T. H.& Yeh, Chi-Tai…[et al.]. BlueBerry Isolate, Pterostilbene, Functions as a Potential Anticancer Stem Cell Agent in Suppressing Irradiation-Mediated Enrichment of Hepatoma Stem Cells. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-458085
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-458085