Bevacizumab and Weekly Docetaxel in Patients with Metastatic Castrate-Resistant Prostate Cancer Previously Exposed to Docetaxel
Joint Authors
Petrioli, Roberto
Chiriacò, Giorgio
Francini, Filippo
Bargagli, Gianluca
Martellucci, Ignazio
Savelli, Vinno
Roviello, Giandomenico
Manganelli, Antonio
Francini, Edoardo
Ponchietti, Roberto
Conca, Raffaele
Pascucci, Alessandra
Marzocca, Giuseppe
Miano, Salvatora Tindara
Licchetta, Antonella
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-08-21
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
The aim of this paper was to evaluate the activity and tolerability of docetaxel (D) and bevacizumab (Bev) in patients with metastatic castrate-resistant prostate cancer (CRPC) previously exposed to D.
Methods.
Treatment consisted of D 30 mg/m2 i.v.
for four consecutive weekly administrations followed by a 2-week rest interval, in addition to Bev 5 mg/kg i.v.
every 2 weeks.
Results.
Forty-three patients were enrolled: a PSA response was observed in 27 patients (62.7%, 95% CI: 0.41 to 0.91), and a palliative response was achieved in 31 patients (72.1%, 95%CI: 0.48 to 1.02).
After a median followup of 11.3 months, only five patients had died.
The regimen was generally well tolerated.
Conclusion.
Weekly D + biweekly Bev seems to be an effective and well-tolerated treatment option for patients with metastatic CRPC previously exposed to D-based chemotherapy.
American Psychological Association (APA)
Francini, Filippo& Pascucci, Alessandra& Francini, Edoardo& Bargagli, Gianluca& Conca, Raffaele& Licchetta, Antonella…[et al.]. 2011. Bevacizumab and Weekly Docetaxel in Patients with Metastatic Castrate-Resistant Prostate Cancer Previously Exposed to Docetaxel. Prostate Cancer،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-458118
Modern Language Association (MLA)
Francini, Filippo…[et al.]. Bevacizumab and Weekly Docetaxel in Patients with Metastatic Castrate-Resistant Prostate Cancer Previously Exposed to Docetaxel. Prostate Cancer No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-458118
American Medical Association (AMA)
Francini, Filippo& Pascucci, Alessandra& Francini, Edoardo& Bargagli, Gianluca& Conca, Raffaele& Licchetta, Antonella…[et al.]. Bevacizumab and Weekly Docetaxel in Patients with Metastatic Castrate-Resistant Prostate Cancer Previously Exposed to Docetaxel. Prostate Cancer. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-458118
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-458118