Immunopathogenesis of Human T-Cell Leukemia Virus Type-1-Associated MyelopathyTropical Spastic Paraparesis : Recent Perspectives
Joint Authors
Bangham, Charles R. M.
Saito, Mineki
Source
Leukemia Research and Treatment
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-06
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Mechanical Engineering
Medicine
Abstract EN
Human T-cell leukemia virus type-1 (HTLV-1) is a replication-competent human retrovirus associated with two distinct types of disease only in a minority of infected individuals: the malignancy known as adult T-cell leukemia (ATL) and a chronic inflammatory central nervous system disease HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP).
HAM/TSP is a chronic progressive myelopathy characterized by spastic paraparesis, sphincter dysfunction, and mild sensory disturbance in the lower extremities.
Although the factors that cause these different manifestations of HTLV-1 infection are not fully understood, accumulating evidence from host population genetics, viral genetics, DNA expression microarrays, and assays of lymphocyte function suggests that complex virus-host interactions and the host immune response play an important role in the pathogenesis of HAM/TSP.
Especially, the efficiency of an individual's cytotoxic T-cell (CTL) response to HTLV-1 limits the HTLV-1 proviral load and the risk of HAM/TSP.
This paper focuses on the recent advances in HAM/TSP research with the aim to identify the precise mechanisms of disease, in order to develop effective treatment and prevention.
American Psychological Association (APA)
Saito, Mineki& Bangham, Charles R. M.. 2012. Immunopathogenesis of Human T-Cell Leukemia Virus Type-1-Associated MyelopathyTropical Spastic Paraparesis : Recent Perspectives. Leukemia Research and Treatment،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-458138
Modern Language Association (MLA)
Saito, Mineki& Bangham, Charles R. M.. Immunopathogenesis of Human T-Cell Leukemia Virus Type-1-Associated MyelopathyTropical Spastic Paraparesis : Recent Perspectives. Leukemia Research and Treatment No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-458138
American Medical Association (AMA)
Saito, Mineki& Bangham, Charles R. M.. Immunopathogenesis of Human T-Cell Leukemia Virus Type-1-Associated MyelopathyTropical Spastic Paraparesis : Recent Perspectives. Leukemia Research and Treatment. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-458138
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-458138