Effect of Pioglitazone on the Fructose-Induced Abdominal Adipose Tissue Dysfunction
Joint Authors
Alzamendi, Ana
Gagliardino, Juan J.
Rebolledo, Oscar R.
García, María E.
Giovambattista, Andrés
Spinedi, Eduardo
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-10-02
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Aim.
To test the potential role of PPARγ in the endocrine abdominal tissue dysfunction induced by feeding normal rats with a fructose rich diet (FRD) during three weeks.
Methodology.
Adult normal male rats received a standard commercial diet (CD) or FRD, (10% in drinking water) without or with pioglitazone (PIO) (i.p.
0.25 mg/Kg BW/day; CD-PIO and FRD-PIO).
Thereafter, we measured circulating metabolic, endocrine, and oxidative stress (OS) markers, abdominal adipose tissue (AAT) mass, leptin (LEP) and plasminogen activator inhibitor-1 (PAI-1) tissue content/expression, and leptin release by isolated adipocytes incubated with different concentrations of insulin.
Results.
Plasma glucose, insulin, triglyceride, TBARS, LEP, and PAI-1 levels were higher in FRD rats; PIO coadministration fully prevented all these increments.
AAT adipocytes from FRD rats were larger, secreted a higher amount of LEP, and displayed decreased sensitivity to insulin stimulation; these effects were significantly ameliorated by PIO.
Whereas AAT LEP and PAI-1 (mRNA) concentrations increased significantly in FRD rats, those of insulin-receptor-substrate- (IRS-) 1 and IRS-2 were reduced.
PIO coadministration prevented FRD effects on LEP, PAI-1, and IRS-2 (fully) and IRS-1 (partially) mRNAs in AAT.
Conclusion.
PPARγ would play a relevant role in the development of the FRD-induced metabolic-endocrine dysfunction.
American Psychological Association (APA)
Alzamendi, Ana& Giovambattista, Andrés& García, María E.& Rebolledo, Oscar R.& Gagliardino, Juan J.& Spinedi, Eduardo. 2012. Effect of Pioglitazone on the Fructose-Induced Abdominal Adipose Tissue Dysfunction. PPAR Research،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-458147
Modern Language Association (MLA)
Alzamendi, Ana…[et al.]. Effect of Pioglitazone on the Fructose-Induced Abdominal Adipose Tissue Dysfunction. PPAR Research No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-458147
American Medical Association (AMA)
Alzamendi, Ana& Giovambattista, Andrés& García, María E.& Rebolledo, Oscar R.& Gagliardino, Juan J.& Spinedi, Eduardo. Effect of Pioglitazone on the Fructose-Induced Abdominal Adipose Tissue Dysfunction. PPAR Research. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-458147
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-458147