Bio-Inspired Microsystem for Robust Genetic Assay Recognition
Joint Authors
Lue, Jaw-Chyng L.
Fang, Wai-Chi
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2008-06-11
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
A compact integrated system-on-chip (SoC) architecture solution for robust, real-time, and on-site genetic analysis has been proposed.
This microsystem solution is noise-tolerable and suitable for analyzing the weak fluorescence patterns from a PCR prepared dual-labeled DNA microchip assay.
In the architecture, a preceding VLSI differential logarithm microchip is designed for effectively computing the logarithm of the normalized input fluorescence signals.
A posterior VLSI artificial neural network (ANN) processor chip is used for analyzing the processed signals from the differential logarithm stage.
A single-channel logarithmic circuit was fabricated and characterized.
A prototype ANN chip with unsupervised winner-take-all (WTA) function was designed, fabricated, and tested.
An ANN learning algorithm using a novel sigmoid-logarithmic transfer function based on the supervised backpropagation (BP) algorithm is proposed for robustly recognizing low-intensity patterns.
Our results show that the trained new ANN can recognize low-fluorescence patterns better than an ANN using the conventional sigmoid function.
American Psychological Association (APA)
Lue, Jaw-Chyng L.& Fang, Wai-Chi. 2008. Bio-Inspired Microsystem for Robust Genetic Assay Recognition. Journal of Biomedicine and Biotechnology،Vol. 2008, no. 2008, pp.1-10.
https://search.emarefa.net/detail/BIM-458157
Modern Language Association (MLA)
Lue, Jaw-Chyng L.& Fang, Wai-Chi. Bio-Inspired Microsystem for Robust Genetic Assay Recognition. Journal of Biomedicine and Biotechnology No. 2008 (2008), pp.1-10.
https://search.emarefa.net/detail/BIM-458157
American Medical Association (AMA)
Lue, Jaw-Chyng L.& Fang, Wai-Chi. Bio-Inspired Microsystem for Robust Genetic Assay Recognition. Journal of Biomedicine and Biotechnology. 2008. Vol. 2008, no. 2008, pp.1-10.
https://search.emarefa.net/detail/BIM-458157
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-458157