Differential Expression of Matrix Metalloproteinase-2 Expression in Disseminated Tumor Cells and Micrometastasis in Bone Marrow of Patients with Nonmetastatic and Metastatic Prostate Cancer : Theoretical Considerations and Clinical Implications—An Immunocytochemical Study
Joint Authors
Tapia, Pablo
Badínez, Leonardo
Murray, Nigel P.
Reyes, Eduardo
Orellana, Nelson
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-11-26
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Matrix metalloproteinase-2 (MMP-2) is important in the dissemination and invasion of tumor cells and activates angiogenesis.
We present an immunocytochemical study of MMP-2 expression in circulating prostate cells (CPCs), disseminated tumor cells (DTCs), and micrometastasis (mM) in bone marrow of men with prostate cancer.
Methods and Patients.
Tumor cells were identified with anti-PSA immunocytochemistry.
Positive samples underwent processing with anti-MMP-2, its expression was compared with Gleason score, concordance of expression, and metastatic and nonmetastatic disease.
Results.
215 men participated, CPCs were detected in 62.7%, DTCs in 62.2%, and mM in 71.4% in nonmetastatic cancer; in metastatic cancer all had CPCs, DTCs, and mM detected.
All CPCs and DTCs expressed MMP-2; in mM MMP-2 expression was positively associated with increasing Gleason score.
MMP-2 expression in CPCs and DTCs showed concordance.
In low grade tumors, mM and surrounding stromal cells were MMP-2 negative, with variable expression in high grade tumors; in metastatic disease, both mM and stromal cells were MMP-2 positive.
Conclusions.
CPCs and DTCs are different from mM, with inhibition of MMP-2 expression in mM of low grade tumors.
With disease progression, MMP-2 expression increases in both mM and surrounding stromal cells, with implications for the use of bisphosphonates or MMP-2 inhibitors.
American Psychological Association (APA)
Murray, Nigel P.& Reyes, Eduardo& Tapia, Pablo& Badínez, Leonardo& Orellana, Nelson. 2012. Differential Expression of Matrix Metalloproteinase-2 Expression in Disseminated Tumor Cells and Micrometastasis in Bone Marrow of Patients with Nonmetastatic and Metastatic Prostate Cancer : Theoretical Considerations and Clinical Implications—An Immunocytochemical Study. Bone Marrow Research،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-458174
Modern Language Association (MLA)
Murray, Nigel P.…[et al.]. Differential Expression of Matrix Metalloproteinase-2 Expression in Disseminated Tumor Cells and Micrometastasis in Bone Marrow of Patients with Nonmetastatic and Metastatic Prostate Cancer : Theoretical Considerations and Clinical Implications—An Immunocytochemical Study. Bone Marrow Research No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-458174
American Medical Association (AMA)
Murray, Nigel P.& Reyes, Eduardo& Tapia, Pablo& Badínez, Leonardo& Orellana, Nelson. Differential Expression of Matrix Metalloproteinase-2 Expression in Disseminated Tumor Cells and Micrometastasis in Bone Marrow of Patients with Nonmetastatic and Metastatic Prostate Cancer : Theoretical Considerations and Clinical Implications—An Immunocytochemical Study. Bone Marrow Research. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-458174
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-458174