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Stem Cell-Based Therapies for Liver Diseases : State of the Art and New Perspectives
Joint Authors
Gasbarrini, Giovanni
Piscaglia, Anna Chiara
Gasbarrini, Antonio
Campanale, Mariachiara
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-09-01
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Abstract EN
Millions of patients worldwide suffer from end-stage liver pathologies, whose only curative therapy is liver transplantation (OLT).
Given the donor organ shortage, alternatives to OLT have been evaluated, including cell therapies.
Hepatocyte transplantation has been attempted to cure metabolic liver disorders and end-stage liver diseases.
The evaluation of its efficacy is complicated by the shortage of human hepatocytes and their difficult expansion and cryopreservation.
Recent advances in cell biology have led to the concept of “regenerative medicine”, based on the therapeutic potential of stem cells (SCs).
Different types of SCs are theoretically eligible for liver cell replacement.
These include embryonic and fetal SCs, induced pluripotent cells, annex SCs, endogenous liver SCs, and extrahepatic adult SCs.
Aim of this paper is to critically analyze the possible sources of SCs suitable for liver repopulation and the results of the clinical trials that have been published until now.
American Psychological Association (APA)
Piscaglia, Anna Chiara& Campanale, Mariachiara& Gasbarrini, Antonio& Gasbarrini, Giovanni. 2010. Stem Cell-Based Therapies for Liver Diseases : State of the Art and New Perspectives. Stem Cells International،Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-458191
Modern Language Association (MLA)
Piscaglia, Anna Chiara…[et al.]. Stem Cell-Based Therapies for Liver Diseases : State of the Art and New Perspectives. Stem Cells International No. 2010 (2010), pp.1-10.
https://search.emarefa.net/detail/BIM-458191
American Medical Association (AMA)
Piscaglia, Anna Chiara& Campanale, Mariachiara& Gasbarrini, Antonio& Gasbarrini, Giovanni. Stem Cell-Based Therapies for Liver Diseases : State of the Art and New Perspectives. Stem Cells International. 2010. Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-458191
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-458191