Endoplasmic Reticulum Stress-Related Inflammation and Cardiovascular Diseases
Joint Authors
Endo, Motoyoshi
Gotoh, Tomomi
Oike, Yuichi
Source
International Journal of Inflammation
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-27
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The endoplasmic reticulum (ER) is the site of synthesis and maturation of proteins designed for secretion or for localization on the cell membrane.
Various types of stress from both inside and outside cells disturb ER function, thus causing unfolded or misfolded proteins to accumulate in the ER.
To improve and maintain the ER functions against such stresses, the ER stress response pathway is activated.
However, when the stress is prolonged or severe, apoptosis pathways are activated to remove damaged cells.
It was recently reported that the ER stress pathway is also involved in the inflammatory response, whereby inflammation induces ER stress, and ER stress induces an inflammatory response.
Therefore, the ER stress response pathway is involved in various diseases, including cardiovascular diseases such as atherosclerosis and ischemic diseases, in various ways.
The ER stress pathway may represent a novel target for the treatment of these diseases.
American Psychological Association (APA)
Gotoh, Tomomi& Endo, Motoyoshi& Oike, Yuichi. 2011. Endoplasmic Reticulum Stress-Related Inflammation and Cardiovascular Diseases. International Journal of Inflammation،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-458192
Modern Language Association (MLA)
Gotoh, Tomomi…[et al.]. Endoplasmic Reticulum Stress-Related Inflammation and Cardiovascular Diseases. International Journal of Inflammation No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-458192
American Medical Association (AMA)
Gotoh, Tomomi& Endo, Motoyoshi& Oike, Yuichi. Endoplasmic Reticulum Stress-Related Inflammation and Cardiovascular Diseases. International Journal of Inflammation. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-458192
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-458192