The Endocannabinoid System and Sex Steroid Hormone-Dependent Cancers
Joint Authors
Taylor, Anthony H.
Marczylo, Timothy H.
Konje, Justin C.
Willets, Jonathon M.
Ayakannu, Thangesweran
Source
International Journal of Endocrinology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-27
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
The “endocannabinoid system (ECS)” comprises the endocannabinoids, the enzymes that regulate their synthesis and degradation, the prototypical cannabinoid receptors (CB1 and CB2), some noncannabinoid receptors, and an, as yet, uncharacterised transport system.
Recent evidence suggests that both cannabinoid receptors are present in sex steroid hormone-dependent cancer tissues and potentially play an important role in those malignancies.
Sex steroid hormones regulate the endocannabinoid system and the endocannabinoids prevent tumour development through putative protective mechanisms that prevent cell growth and migration, suggesting an important role for endocannabinoids in the regulation of sex hormone-dependent tumours and metastasis.
Here, the role of the endocannabinoid system in sex steroid hormone-dependent cancers is described and the potential for novel therapies assessed.
American Psychological Association (APA)
Ayakannu, Thangesweran& Taylor, Anthony H.& Marczylo, Timothy H.& Willets, Jonathon M.& Konje, Justin C.. 2013. The Endocannabinoid System and Sex Steroid Hormone-Dependent Cancers. International Journal of Endocrinology،Vol. 2013, no. 2013, pp.1-14.
https://search.emarefa.net/detail/BIM-458212
Modern Language Association (MLA)
Ayakannu, Thangesweran…[et al.]. The Endocannabinoid System and Sex Steroid Hormone-Dependent Cancers. International Journal of Endocrinology No. 2013 (2013), pp.1-14.
https://search.emarefa.net/detail/BIM-458212
American Medical Association (AMA)
Ayakannu, Thangesweran& Taylor, Anthony H.& Marczylo, Timothy H.& Willets, Jonathon M.& Konje, Justin C.. The Endocannabinoid System and Sex Steroid Hormone-Dependent Cancers. International Journal of Endocrinology. 2013. Vol. 2013, no. 2013, pp.1-14.
https://search.emarefa.net/detail/BIM-458212
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-458212