All-trans-Retinoic Acid Ameliorated High Fat Diet-Induced Atherosclerosis in Rabbits by Inhibiting Platelet Activation and Inflammation
Joint Authors
Pan, Ying
Wang, Yuan
Zhou, Qing
Wang, Xiaobian
Zhou, Birong
Hu, Zeping
Zhai, Zhimin
Han, Jianxiong
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-01
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
All-trans-retinoic acid (atRA) is effective for many proliferative diseases.
We investigated the protective effects of atRA against atherosclerosis.
Methods.
Rabbits were randomly allocated to receive basal diet or an HFD for 4 weeks.
HFD group then received rosuvastatin (3 mg/day), atRA (5 mg/kg/day), or the same volume of vehicle, respectively, for next 8 weeks.
Results.
HFD group showed increases in plasma lipids and aortic plaque formation.
P-selectin expression and fibrinogen binding on platelets or deposition on the intima of the aorta also increased significantly as did the levels of TNF-α, IL-6, and fibrinogen in plasma.
After 8 weeks of treatment with atRA, there was a significant decrease in plasma lipids and improvement in aortic lesions.
AtRA also inhibited the expression of P-selectin and fibrinogen binding on platelets and deposition on the intima of the aorta.
Conclusion.
AtRA can ameliorate HFD-induced AS in rabbits by inhibiting platelet activation and inflammation.
American Psychological Association (APA)
Zhou, Birong& Pan, Ying& Hu, Zeping& Wang, Xiaobian& Han, Jianxiong& Zhou, Qing…[et al.]. 2012. All-trans-Retinoic Acid Ameliorated High Fat Diet-Induced Atherosclerosis in Rabbits by Inhibiting Platelet Activation and Inflammation. Journal of Biomedicine and Biotechnology،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-458215
Modern Language Association (MLA)
Zhou, Birong…[et al.]. All-trans-Retinoic Acid Ameliorated High Fat Diet-Induced Atherosclerosis in Rabbits by Inhibiting Platelet Activation and Inflammation. Journal of Biomedicine and Biotechnology No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-458215
American Medical Association (AMA)
Zhou, Birong& Pan, Ying& Hu, Zeping& Wang, Xiaobian& Han, Jianxiong& Zhou, Qing…[et al.]. All-trans-Retinoic Acid Ameliorated High Fat Diet-Induced Atherosclerosis in Rabbits by Inhibiting Platelet Activation and Inflammation. Journal of Biomedicine and Biotechnology. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-458215
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-458215