The Evidence for Efficacy of Osteoporosis Treatment in Men with Primary Osteoporosis : A Systematic Review and Meta-Analysis of Antiresorptive and Anabolic Treatment in Men
Joint Authors
Vestergaard, Peter
Schwarz, Peter
Mosekilde, Leif
Jorgensen, Niklas Rye
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-24
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Purpose.
Fragility fractures in men constitute a major worldwide public health problem with a life-time risk of 13%.
It cannot be directly inferred that antiosteoporotic drugs effective in women have the same effect in men.
Our aim was to appraise the existing evidence for efficacy of osteoporosis treatment in men.
Methods.
This study was a systematic review of the published literature on the clinical efficacy of medical osteoporosis therapy in the reduction of fracture risk in men (age > 50 years).
Studies included were randomised, placebo-controlled trials of men.
Results.
Five BMD studies of antiresorptive treatment were included.
All studies showed an increase in BMD, but there was only a nonsignificant trend in the reduction of clinical fractures.
Three BMD studies of anabolic treatment with teriparatide were also included.
These showed a significant mean increase in spine BMD and for vertebral fractures a non-significant trend towards a reduction was seen.
Conclusion.
The evidence of medical osteoporosis treatment in men is scant and inconclusive due to the lack of prospective RCT studies with fracture prevention as primary end point.
So far, all evidence is based on BMD increases in small RCT studies showing BMD increases comparable to those reported in postmenopausal women.
American Psychological Association (APA)
Schwarz, Peter& Jorgensen, Niklas Rye& Mosekilde, Leif& Vestergaard, Peter. 2011. The Evidence for Efficacy of Osteoporosis Treatment in Men with Primary Osteoporosis : A Systematic Review and Meta-Analysis of Antiresorptive and Anabolic Treatment in Men. Journal of Osteoporosis،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-458228
Modern Language Association (MLA)
Schwarz, Peter…[et al.]. The Evidence for Efficacy of Osteoporosis Treatment in Men with Primary Osteoporosis : A Systematic Review and Meta-Analysis of Antiresorptive and Anabolic Treatment in Men. Journal of Osteoporosis No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-458228
American Medical Association (AMA)
Schwarz, Peter& Jorgensen, Niklas Rye& Mosekilde, Leif& Vestergaard, Peter. The Evidence for Efficacy of Osteoporosis Treatment in Men with Primary Osteoporosis : A Systematic Review and Meta-Analysis of Antiresorptive and Anabolic Treatment in Men. Journal of Osteoporosis. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-458228
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-458228