Renal Function but Not Asymmetric Dimethylarginine Is Independently Associated with Retinopathy in Type 2 Diabetes
Joint Authors
Aschauer, Stefan
Schernthaner, Guntram
Wolzt, Michael
Schernthaner, Gerit H.
Brix, Johanna M.
Mittermayer, Friedrich
Höllerl, Florian
Krzyzanowska, Katarzyna
Brunner, Simon
Source
Cardiology Research and Practice
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-05-09
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
Asymmetric dimethylarginine (ADMA) is associated with macrovascular disease and possibly with microangiopathy in type 2 diabetes (T2DM).
We tested the hypothesis that ADMA is related to diabetic retinopathy (DR) independently of macrovascular disease.
Methods.
This cross-sectional study included 127 T2DM patients selected to achieve equal distributions of patients with and without macrovascular disease in the groups with and without DR.
Results.
Patients with DR had increased ADMA, longer diabetes duration, and reduced glomerular filtration rate (GFR).
ADMA correlated with GFR (ρ=-0.35; P<.001), diabetes duration (ρ=0.19; P=.048), and age (ρ=0.19; P=.033).
Logistic regression analysis revealed an association of ADMA with DR.
After adjustment for macrovascular disease, this association remained significant (OR 1.48; 95% CI: 1.02–2.15; P=.039).
Inclusion of GFR and T2DM duration into the model abolished this significant relationship.
GFR remained the only independent predictor for DR.
A 10 mL/min/1.73 m2 GFR decrease was associated with DR in a multivariate model (OR 1.30; 95% CI: 1.08–1.56; P=.006).
Conclusions.
These findings indicate an association between ADMA and DR in T2DM independent of macrovascular disease.
This relationship is modified by GFR, the only parameter significantly related to DR in multivariate analysis.
American Psychological Association (APA)
Krzyzanowska, Katarzyna& Mittermayer, Friedrich& Schernthaner, Gerit H.& Brunner, Simon& Brix, Johanna M.& Aschauer, Stefan…[et al.]. 2011. Renal Function but Not Asymmetric Dimethylarginine Is Independently Associated with Retinopathy in Type 2 Diabetes. Cardiology Research and Practice،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-458244
Modern Language Association (MLA)
Krzyzanowska, Katarzyna…[et al.]. Renal Function but Not Asymmetric Dimethylarginine Is Independently Associated with Retinopathy in Type 2 Diabetes. Cardiology Research and Practice No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-458244
American Medical Association (AMA)
Krzyzanowska, Katarzyna& Mittermayer, Friedrich& Schernthaner, Gerit H.& Brunner, Simon& Brix, Johanna M.& Aschauer, Stefan…[et al.]. Renal Function but Not Asymmetric Dimethylarginine Is Independently Associated with Retinopathy in Type 2 Diabetes. Cardiology Research and Practice. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-458244
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-458244