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Effects of Crude Extracts from Medicinal Herbs Rhazya stricta and Zingiber officinale on Growth and Proliferation of Human Brain Cancer Cell Line In Vitro
Joint Authors
Elkady, Ayman I.
Hussein, Rania Abd El Hamid
Abu-Zinadah, Usamah A.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-22
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Hitherto, limited clinical impact has been achieved in the treatment of glioblastoma (GBMs).
Although phytochemicals found in medicinal herbs can provide mankind with new therapeutic remedies, single agent intervention has failed to bring the expected outcome in clinical trials.
Therefore, combinations of several agents at once are gaining increasing attractiveness.
In the present study, we investigated the effects of crude alkaloid (CAERS) and flavonoid (CFEZO) extracts prepared from medicinal herbs, Rhazya stricta and Zingiber officinale, respectively, on the growth of human GBM cell line, U251.
R.
stricta and Z.
officinale are traditionally used in folkloric medicine and have antioxidant, anticarcinogenic, and free radical scavenging properties.
Combination of CAERS and CFEZO treatments synergistically suppressed proliferation and colony formation and effectively induced morphological and biochemical features of apoptosis in U251 cells.
Apoptosis induction was mediated by release of mitochondrial cytochrome c, increased Bax : Bcl-2 ratio, enhanced activities of caspase-3 and -9, and PARP-1 cleavage.
CAERS and CFEZO treatments decreased expression levels of nuclear NF-κBp65, survivin, XIAP, and cyclin D1 and increased expression level of p53, p21, and Noxa.
These results suggest that combination of CAERS and CFEZO provides a useful foundation for studying and developing novel chemotherapeutic agents for the treatment of GBM.
American Psychological Association (APA)
Elkady, Ayman I.& Hussein, Rania Abd El Hamid& Abu-Zinadah, Usamah A.. 2014. Effects of Crude Extracts from Medicinal Herbs Rhazya stricta and Zingiber officinale on Growth and Proliferation of Human Brain Cancer Cell Line In Vitro. BioMed Research International،Vol. 2014, no. 2014, pp.1-16.
https://search.emarefa.net/detail/BIM-458247
Modern Language Association (MLA)
Elkady, Ayman I.…[et al.]. Effects of Crude Extracts from Medicinal Herbs Rhazya stricta and Zingiber officinale on Growth and Proliferation of Human Brain Cancer Cell Line In Vitro. BioMed Research International No. 2014 (2014), pp.1-16.
https://search.emarefa.net/detail/BIM-458247
American Medical Association (AMA)
Elkady, Ayman I.& Hussein, Rania Abd El Hamid& Abu-Zinadah, Usamah A.. Effects of Crude Extracts from Medicinal Herbs Rhazya stricta and Zingiber officinale on Growth and Proliferation of Human Brain Cancer Cell Line In Vitro. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-16.
https://search.emarefa.net/detail/BIM-458247
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-458247