Focus on Adoptive T Cell Transfer Trials in Melanoma
Joint Authors
Hershkovitz, Liat
Besser, Michal J.
Jacob, Schachter
Treves, Avraham J.
Source
Clinical and Developmental Immunology
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-12-26
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Adoptive Cell Transfer (ACT) of Tumor-Infiltrating Lymphocytes (TIL) in combination with lymphodepletion has proven to be an effective treatment for metastatic melanoma patients, with an objective response rate in 50%–70% of the patients.
It is based on the ex vivo expansion and activation of tumor-specific T lymphocytes extracted from the tumor and their administration back to the patient.
Various TIL-ACT trials, which differ in their TIL generation procedures and patient preconditioning, have been reported.
In the latest clinical studies, genetically engineered peripheral T cells were utilized instead of TIL.
Further improvement of adoptive T cell transfer depends on new investigations which seek higher TIL quality, increased durable response rates, and aim to treat more patients.
Simplifying this therapy may encourage cancer centers worldwide to adopt this promising technology.
This paper focuses on the latest progress regarding adoptive T cell transfer, comparing the currently available protocols and discussing their advantages, disadvantages, and implication in the future.
American Psychological Association (APA)
Hershkovitz, Liat& Jacob, Schachter& Treves, Avraham J.& Besser, Michal J.. 2010. Focus on Adoptive T Cell Transfer Trials in Melanoma. Clinical and Developmental Immunology،Vol. 2010, no. 2010, pp.1-11.
https://search.emarefa.net/detail/BIM-458252
Modern Language Association (MLA)
Hershkovitz, Liat…[et al.]. Focus on Adoptive T Cell Transfer Trials in Melanoma. Clinical and Developmental Immunology No. 2010 (2010), pp.1-11.
https://search.emarefa.net/detail/BIM-458252
American Medical Association (AMA)
Hershkovitz, Liat& Jacob, Schachter& Treves, Avraham J.& Besser, Michal J.. Focus on Adoptive T Cell Transfer Trials in Melanoma. Clinical and Developmental Immunology. 2010. Vol. 2010, no. 2010, pp.1-11.
https://search.emarefa.net/detail/BIM-458252
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-458252