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Consequences of Hyperoxia and the Toxicity of Oxygen in the Lung
Joint Authors
Pierce, J. Thomas
Pierce, Janet D.
Thimmesch, Amanda R.
Mach, William J.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-05
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Oxygen (O2) is life essential but as a drug has a maximum positive biological benefit and accompanying toxicity effects.
Oxygen is therapeutic for treatment of hypoxemia and hypoxia associated with many pathological processes.
Pathophysiological processes are associated with increased levels of hyperoxia-induced reactive O2 species (ROS) which may readily react with surrounding biological tissues, damaging lipids, proteins, and nucleic acids.
Protective antioxidant defenses can become overwhelmed with ROS leading to oxidative stress.
Activated alveolar capillary endothelium is characterized by increased adhesiveness causing accumulation of cell populations such as neutrophils, which are a source of ROS.
Increased levels of ROS cause hyperpermeability, coagulopathy, and collagen deposition as well as other irreversible changes occurring within the alveolar space.
In hyperoxia, multiple signaling pathways determine the pulmonary cellular response: apoptosis, necrosis, or repair.
Understanding the effects of O2 administration is important to prevent inadvertent alveolar damage caused by hyperoxia in patients requiring supplemental oxygenation.
American Psychological Association (APA)
Mach, William J.& Thimmesch, Amanda R.& Pierce, J. Thomas& Pierce, Janet D.. 2011. Consequences of Hyperoxia and the Toxicity of Oxygen in the Lung. Nursing Research and Practice،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-458270
Modern Language Association (MLA)
Mach, William J.…[et al.]. Consequences of Hyperoxia and the Toxicity of Oxygen in the Lung. Nursing Research and Practice No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-458270
American Medical Association (AMA)
Mach, William J.& Thimmesch, Amanda R.& Pierce, J. Thomas& Pierce, Janet D.. Consequences of Hyperoxia and the Toxicity of Oxygen in the Lung. Nursing Research and Practice. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-458270
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-458270