A Tandem Repeat in Decay Accelerating Factor 1 Is Associated with Severity of Murine Mercury-Induced Autoimmunity
Joint Authors
Kono, Dwight H.
Cauvi, David M.
Gabriel, Rodney
Pollard, K. Michael
Hultman, Per
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-10
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Decay accelerating factor (DAF), a complement-regulatory protein, protects cells from bystander complement-mediated lysis and negatively regulates T cells.
Reduced expression of DAF occurs in several systemic autoimmune diseases including systemic lupus erythematosus, and DAF deficiency exacerbates disease in several autoimmune models, including murine mercury-induced autoimmunity (mHgIA).
Daf1, located within Hmr1, a chromosome 1 locus associated in DBA/2 mice with resistance to mHgIA, could be a candidate.
Here we show that reduced Daf1 transcription in lupus-prone mice was not associated with a reduction in the Daf1 transcription factor SP1.
Studies of NZB mice congenic for the mHgIA-resistant DBA/2 Hmr1 locus suggested that Daf1 expression was controlled by the host genome and not the Hmr1 locus.
A unique pentanucleotide repeat variant in the second intron of Daf1 in DBA/2 mice was identified and shown in F2 intercrosses to be associated with less severe disease; however, analysis of Hmr1 congenics indicated that this most likely reflected the presence of autoimmunity-predisposing genetic variants within the Hmr1 locus or that Daf1 expression is mediated by the tandem repeat in epistasis with other genetic variants present in autoimmune-prone mice.
These studies argue that the effect of DAF on autoimmunity is complex and may require multiple genetic elements.
American Psychological Association (APA)
Cauvi, David M.& Gabriel, Rodney& Kono, Dwight H.& Hultman, Per& Pollard, K. Michael. 2014. A Tandem Repeat in Decay Accelerating Factor 1 Is Associated with Severity of Murine Mercury-Induced Autoimmunity. Autoimmune Diseases،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-458284
Modern Language Association (MLA)
Cauvi, David M.…[et al.]. A Tandem Repeat in Decay Accelerating Factor 1 Is Associated with Severity of Murine Mercury-Induced Autoimmunity. Autoimmune Diseases No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-458284
American Medical Association (AMA)
Cauvi, David M.& Gabriel, Rodney& Kono, Dwight H.& Hultman, Per& Pollard, K. Michael. A Tandem Repeat in Decay Accelerating Factor 1 Is Associated with Severity of Murine Mercury-Induced Autoimmunity. Autoimmune Diseases. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-458284
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-458284