The Role of Mirk Kinase in Sarcomas
Author
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-04-13
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Targeting the tyrosine kinase KIT in gastrointestinal stromal tumors has led to improved treatment.
Other kinases might serve as therapeutic targets in the more common forms of sarcoma.
The kinase Mirk/dyrk1B is highly expressed in the vast majority of osteosarcomas and rhabdomyosarcomas and mediates their growth, as depletion of Mirk led to tumor cell apoptosis.
Mirk is known to increase the expression of a series of antioxidant genes, which scavenge reactive oxygen species (ROS) within various tumor cells, mediating their survival.
As a result, depleting Mirk led to increased levels of damaging ROS.
Tumor cells depleted of Mirk were also sensitized to low levels of chemotherapeutic drugs that increase ROS levels.
In contrast, Mirk expression is quite low in most normal cells, and Mirk depletion or embryonic knockout of Mirk did not detectably affect cell survival.
Thus targeting Mirk for intervention in sarcomas might spare most normal tissues.
American Psychological Association (APA)
Friedman, Eileen. 2011. The Role of Mirk Kinase in Sarcomas. Sarcoma،Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-458295
Modern Language Association (MLA)
Friedman, Eileen. The Role of Mirk Kinase in Sarcomas. Sarcoma No. 2011 (2011), pp.1-5.
https://search.emarefa.net/detail/BIM-458295
American Medical Association (AMA)
Friedman, Eileen. The Role of Mirk Kinase in Sarcomas. Sarcoma. 2011. Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-458295
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-458295