Effluent Markers Related to Epithelial Mesenchymal Transition with Adjusted Values for Effluent Cancer Antigen 125 in Peritoneal Dialysis Patients

Joint Authors

Aikawa, Atsushi
Hattori, Yoshinari
Muto, Atsuhiko
Tai, Reibin
Suzuki, Yasunori
Ohashi, Yasushi
Sakai, Ken
Mizuiri, Sonoo
Hemmi, Hiromichi
Arita, Michitsune

Source

International Journal of Nephrology

Issue

Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-5, 5 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2011-07-06

Country of Publication

Egypt

No. of Pages

5

Main Subjects

Diseases
Medicine

Abstract EN

Objectives.

Epithelial mesenchymal transition (EMT) is important for peritoneal deterioration.

We evaluated the association between peritoneal solute transport rate (PSTR) and effluent markers related to EMT with adjusted values for effluent cancer antigen 125 (CA125).

Methods.

One hundred five incident peritoneal dialysis (PD) patients on PD for 25 (12–68) months with biocompatible solutions were included in the study.

Fast peritoneal equilibration test was used to evaluate PSTR.

Effluent hepatocyte growth factor (HGF), bone morphogenic protein-7 (BMP-7), vascular endothelial growth factor (VEGF), interleukin-6 (IL-6), and CA125 at 4 h were measured.

Results.

Patients with dialysate/plasma creatinine ≧0.82 showed significantly higher effluent HGF (240 versus 133 pg/mL, P<.001), VEGF, IL-6, and IL6/CA125 levels than the others but no significant differences in effluent HGF/CA125, BMP-7, and BMP7/CA125 were observed.

Conclusion.

Increase in the effluent HGF levels as a compensatory mechanism is a marker of peritoneal deterioration, but controversy remains regarding adjusted value for CA125.

American Psychological Association (APA)

Mizuiri, Sonoo& Hemmi, Hiromichi& Arita, Michitsune& Tai, Reibin& Hattori, Yoshinari& Muto, Atsuhiko…[et al.]. 2011. Effluent Markers Related to Epithelial Mesenchymal Transition with Adjusted Values for Effluent Cancer Antigen 125 in Peritoneal Dialysis Patients. International Journal of Nephrology،Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-458320

Modern Language Association (MLA)

Mizuiri, Sonoo…[et al.]. Effluent Markers Related to Epithelial Mesenchymal Transition with Adjusted Values for Effluent Cancer Antigen 125 in Peritoneal Dialysis Patients. International Journal of Nephrology No. 2011 (2011), pp.1-5.
https://search.emarefa.net/detail/BIM-458320

American Medical Association (AMA)

Mizuiri, Sonoo& Hemmi, Hiromichi& Arita, Michitsune& Tai, Reibin& Hattori, Yoshinari& Muto, Atsuhiko…[et al.]. Effluent Markers Related to Epithelial Mesenchymal Transition with Adjusted Values for Effluent Cancer Antigen 125 in Peritoneal Dialysis Patients. International Journal of Nephrology. 2011. Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-458320

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-458320