Actin Is a Target of T-Cell Reactivity in Patients with Advanced Carotid Atherosclerotic Plaques
Joint Authors
Petrone, Linda
Tesori, Maria Chiara
Buttari, Brigitta
Riganò, Rachele
Profumo, Elisabetta
Lacroce, Giada
Salvati, Bruno
Capoano, Raffaele
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-11
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Atherosclerosis is a chronic inflammatory disease of the arterial wall associated with autoimmune reactions.
In a previous study, we observed the presence of actin-specific antibodies in sera from patients with carotid atherosclerosis.
To extend our previous results we evaluated the possible role of actin as antigenic target of cell-mediated immune reactions in carotid atherosclerosis.
Peripheral blood mononuclear cells (PBMC) from 17 patients and 16 healthy subjects were tested by cell proliferation assay and by ELISA for cytokine production.
Actin induced a proliferative response in 47% of patients’ PBMC samples, with SI ranging from 2.6 to 21.1, and in none of the healthy subjects’ samples (patients versus healthy subjects, P=0.02).
The presence of diabetes in patients was significantly associated with proliferative response to actin (P=0.04).
IFN-γ and TNF-α concentrations were higher in PBMC from patients than in those from healthy subjects and in PBMC proliferating to actin than in nonproliferating ones.
Our data demonstrate for the first time a role of actin as a target autoantigen of cellular immune reactions in patients with carotid atherosclerosis.
The preferential proinflammatory Th1 activation suggests that actin could contribute to endothelial dysfunction, tissue damage, and systemic inflammation in carotid atherosclerosis.
American Psychological Association (APA)
Profumo, Elisabetta& Buttari, Brigitta& Petrone, Linda& Lacroce, Giada& Tesori, Maria Chiara& Capoano, Raffaele…[et al.]. 2013. Actin Is a Target of T-Cell Reactivity in Patients with Advanced Carotid Atherosclerotic Plaques. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-458323
Modern Language Association (MLA)
Profumo, Elisabetta…[et al.]. Actin Is a Target of T-Cell Reactivity in Patients with Advanced Carotid Atherosclerotic Plaques. Mediators of Inflammation No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-458323
American Medical Association (AMA)
Profumo, Elisabetta& Buttari, Brigitta& Petrone, Linda& Lacroce, Giada& Tesori, Maria Chiara& Capoano, Raffaele…[et al.]. Actin Is a Target of T-Cell Reactivity in Patients with Advanced Carotid Atherosclerotic Plaques. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-458323
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-458323