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Gastric Antiulcerogenic and Hypokinetic Activities of Terminalia fagifolia Mart. & Zucc. (Combretaceae)
Joint Authors
Véras, Leiz Maria
Martins, Maria do Carmo C.
Chaves, Mariana H.
Sousa, Elcilene A.
Almeida, Fernanda Regina C.
Nunes, Paulo Humberto M.
Leite, José Roberto de S. A.
Oliveira, Rita de Cássia Meneses
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-12
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
The acute toxicity, the antioxidant activity, and the pharmacological activity on the gastrointestinal tract of rodents of the ethanolic extract (TFEE) from the bark of Terminalia fagifolia Mart.
& Zucc.
(Combretaceae) and of its aqueous (TFAqF), hydroalcoholic (TFHAF), and hexanic (TFHEXF) partition fractions have been evaluated.
TFEE presented low acute toxicity, antioxidant, and antiulcerogenic activity against ethanol-induced ulcers, which was partially blocked by pretreatment with L-NAME and indomethacin.
It reduced the total acidity and raised the pH of gastric secretion.
Additionally, TFEE delayed gastric emptying and slightly inhibited the small intestinal transit and also presented a weakly antidiarrheal activity.
The antiulcerogenic and antioxidant activity were also detected in TFAqF and TFHAF but not in TFHEXF.
The antisecretory and gastroprotective activity of TFEE partially involve the nitric oxide and prostaglandin participation.
Nevertheless, TFEE, TFAqF, and TFHAF drastically reduced the mucus layer adhered to the gastric wall of rats treated with ethanol or indomethacin.
Complementary studies are required in order to clarify the paradox of the presence of a gastroprotector activity in this plant that, at the same time, reduces the mucus layer adhered to the gastric wall.
American Psychological Association (APA)
Nunes, Paulo Humberto M.& Martins, Maria do Carmo C.& Oliveira, Rita de Cássia Meneses& Chaves, Mariana H.& Sousa, Elcilene A.& Leite, José Roberto de S. A.…[et al.]. 2014. Gastric Antiulcerogenic and Hypokinetic Activities of Terminalia fagifolia Mart. & Zucc. (Combretaceae). BioMed Research International،Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-458394
Modern Language Association (MLA)
Nunes, Paulo Humberto M.…[et al.]. Gastric Antiulcerogenic and Hypokinetic Activities of Terminalia fagifolia Mart. & Zucc. (Combretaceae). BioMed Research International No. 2014 (2014), pp.1-14.
https://search.emarefa.net/detail/BIM-458394
American Medical Association (AMA)
Nunes, Paulo Humberto M.& Martins, Maria do Carmo C.& Oliveira, Rita de Cássia Meneses& Chaves, Mariana H.& Sousa, Elcilene A.& Leite, José Roberto de S. A.…[et al.]. Gastric Antiulcerogenic and Hypokinetic Activities of Terminalia fagifolia Mart. & Zucc. (Combretaceae). BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-458394
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-458394