Validation of the Friedewald Formula in Patients with Metabolic Syndrome
Joint Authors
Streisky, Larissa
Olandoski, Marcia
Bandeira, Antonio Milton
Disserol, Caio César Diniz
Knopfholz, José
Takito, Lilian Lumi
Schirr, Fernanda Letícia
Pierin, Andressa Jardim
Faria-Neto, José Rocha
Massucheto Ledesma, Patrícia
da Cunha, Claudio Leinig Pereira
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-06
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Currently, the Friedewald formula (FF) is the main method for evaluating low-density lipoprotein cholesterol (LDL-c).
Recently, many limitations have emerged regarding its use, including patients with triglyceride levels ≥400 mg/dL, diabetes mellitus, and kidney or hepatic chronic diseases.
We analyzed the use of the FF in patients with metabolic syndrome.
We selected patients with known metabolic syndrome that fulfilled the National Cholesterol Education Program Expert Panel on Detection, Evaluation and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) Final Report and excluded patients with triglyceride levels ≥400 mg/dL and chronic liver and/or kidney disease.
Using direct assays, we measured total cholesterol, high-density lipoprotein cholesterol, triglycerides, and LDL-c.
Then, LDL-c was estimated using the FF and compared with the LDL-c by direct assay.
The sample size was 135 patients.
Using the FF, the mean LDL-c value was 124.4±42.1 mg/dL; it was 125.1±38.5 mg/dL by direct assay.
The correlation coefficient between these two methods was 0.89, with statistical significance (P value<0.001).
There were no significant differences between the patients with triglyceride levels >150 mg/dL (P=0.618).
In conclusion, FF is a good method for estimating LDL-c in patients with metabolic syndrome.
American Psychological Association (APA)
Knopfholz, José& Disserol, Caio César Diniz& Pierin, Andressa Jardim& Schirr, Fernanda Letícia& Streisky, Larissa& Takito, Lilian Lumi…[et al.]. 2014. Validation of the Friedewald Formula in Patients with Metabolic Syndrome. Cholesterol،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-458412
Modern Language Association (MLA)
Knopfholz, José…[et al.]. Validation of the Friedewald Formula in Patients with Metabolic Syndrome. Cholesterol No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-458412
American Medical Association (AMA)
Knopfholz, José& Disserol, Caio César Diniz& Pierin, Andressa Jardim& Schirr, Fernanda Letícia& Streisky, Larissa& Takito, Lilian Lumi…[et al.]. Validation of the Friedewald Formula in Patients with Metabolic Syndrome. Cholesterol. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-458412
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-458412