Diffuse Large B-Cell Lymphoma in Human T-Lymphotropic Virus Type 1 Carriers

Abstract EN

We describe the clinical and pathological characteristics of seven patients who were human T-lymphotropic virus type 1 (HTLV-1) carriers and had a pathological diagnosis of de novo diffuse large B-cell lymphoma.

Interestingly, three of our cases showed positive expression of Epstein-Barr-virus, (EBV-) encoded RNA within the tumor cells indicating a possible interaction between these two viruses.

Furthermore, our three EBV-positive cases presented with similar clinical characteristics such as early clinical stage and low-risk indices.

To the best of our knowledge, this is the first case series describing the characteristics of HTLV-1-positive DLBCL patients.

The potential relationship between HTLV-1 and EBV should be further explored.