Towards an Understanding of the Herpes Simplex Virus Type 1 Latency-Reactivation Cycle
Joint Authors
Perng, Guey Chuen
Jones, Clinton
Source
Interdisciplinary Perspectives on Infectious Diseases
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-18, 18 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-02-15
Country of Publication
Egypt
No. of Pages
18
Main Subjects
Abstract EN
Infection by herpes simplex virus type 1 (HSV-1) can cause clinical symptoms in the peripheral and central nervous system.
Recurrent ocular shedding can lead to corneal scarring and vision loss making HSV-1 a leading cause of corneal blindness due to an infectious agent.
The primary site of HSV-1 latency is sensory neurons within trigeminal ganglia.
Periodically, reactivation from latency occurs resulting in virus transmission and recurrent disease.
During latency, the latency-associated transcript (LAT) is abundantly expressed.
LAT expression is important for the latency-reactivation cycle in animal models, in part, because it inhibits apoptosis, viral gene expression, and productive infection.
A novel transcript within LAT coding sequences (AL3) and small nonprotein coding RNAs are also expressed in trigeminal ganglia of latently infected mice.
In this review, an update of viral factors that are expressed during latency and their potential roles in regulating the latency-reactivation cycle is discussed.
American Psychological Association (APA)
Perng, Guey Chuen& Jones, Clinton. 2010. Towards an Understanding of the Herpes Simplex Virus Type 1 Latency-Reactivation Cycle. Interdisciplinary Perspectives on Infectious Diseases،Vol. 2010, no. 2010, pp.1-18.
https://search.emarefa.net/detail/BIM-458458
Modern Language Association (MLA)
Perng, Guey Chuen& Jones, Clinton. Towards an Understanding of the Herpes Simplex Virus Type 1 Latency-Reactivation Cycle. Interdisciplinary Perspectives on Infectious Diseases No. 2010 (2010), pp.1-18.
https://search.emarefa.net/detail/BIM-458458
American Medical Association (AMA)
Perng, Guey Chuen& Jones, Clinton. Towards an Understanding of the Herpes Simplex Virus Type 1 Latency-Reactivation Cycle. Interdisciplinary Perspectives on Infectious Diseases. 2010. Vol. 2010, no. 2010, pp.1-18.
https://search.emarefa.net/detail/BIM-458458
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-458458