The Changing Epidemiology of Oropharyngeal Candidiasis in Patients with HIVAIDS in the Era of Antiretroviral Therapy
Joint Authors
Wickes, Brian L.
Redding, Spencer W.
Erlandsen, Joshua E.
Kirkpatrick, William R.
Westbrook, Steven D.
Patel, Payal K.
Patterson, Thomas F.
Thompson, George R.
Wiederhold, Nathan P.
Vallor, Ana C.
Cornell, John E.
Louden, Christopher
Berg, Deborah K.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-08-28
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
The impact of antiretroviral therapy (ART) on opportunistic conditions in HIV patients continues to evolve.
We specifically studied the changing epidemiology of oropharyngeal candidiasis (OPC) in 215 HIV/AIDS patients.
Status of yeast colonization was assessed from oral rinse samples, and preliminary yeast identification was made using CHROMagar Candida and confirmed with standard microbiological techniques and/or molecular sequencing.
Susceptibility to fluconazole was determined by CHROMagar Candida agar dilution screening and CLSI broth microdilution.
176 (82%) patients were colonized and 59 (27%) patients had symptomatic OPC.
Candida albicans was the most prevalent species, though C.
glabrata and C.
dubliniensis were detected in 29% of isolates.
Decreased fluconazole susceptibility occurred in 10% of isolates.
Previous ART reduced the risk of OPC, while smoking increased the risk of colonization.
Oral yeast colonization and symptomatic infection remain common even with advances in HIV therapy.
C.
albicans is the most common species, but other yeasts are prevalent and may have decreased susceptibility to fluconazole.
American Psychological Association (APA)
Patel, Payal K.& Erlandsen, Joshua E.& Kirkpatrick, William R.& Berg, Deborah K.& Westbrook, Steven D.& Louden, Christopher…[et al.]. 2012. The Changing Epidemiology of Oropharyngeal Candidiasis in Patients with HIVAIDS in the Era of Antiretroviral Therapy. AIDS Research and Treatment،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-458463
Modern Language Association (MLA)
Patel, Payal K.…[et al.]. The Changing Epidemiology of Oropharyngeal Candidiasis in Patients with HIVAIDS in the Era of Antiretroviral Therapy. AIDS Research and Treatment No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-458463
American Medical Association (AMA)
Patel, Payal K.& Erlandsen, Joshua E.& Kirkpatrick, William R.& Berg, Deborah K.& Westbrook, Steven D.& Louden, Christopher…[et al.]. The Changing Epidemiology of Oropharyngeal Candidiasis in Patients with HIVAIDS in the Era of Antiretroviral Therapy. AIDS Research and Treatment. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-458463
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-458463