Cyclodextrin-Containing Polymers : Versatile Platforms of Drug Delivery Materials
Joint Authors
Schluep, Thomas
Heidel, Jeremy D.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-02
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
Nanoparticles are being widely explored as potential therapeutics for numerous applications in medicine and have been shown to significantly improve the circulation, biodistribution, efficacy, and safety profiles of multiple classes of drugs.
One leading class of nanoparticles involves the use of linear, cyclodextrin-containing polymers (CDPs).
As is discussed in this paper, CDPs can incorporate therapeutic payloads into nanoparticles via covalent attachment of prodrug/drug molecules to the polymer (the basis of the Cyclosert platform) or by noncovalent inclusion of cationic CDPs to anionic, nucleic acid payloads (the basis of the RONDEL platform).
For each of these two approaches, we review the relevant molecular architecture and its rationale, discuss the physicochemical and biological properties of these nanoparticles, and detail the progress of leading drug candidates for each that have achieved clinical evaluation.
Finally, we look ahead to potential future directions of investigation and product candidates based upon this technology.
American Psychological Association (APA)
Heidel, Jeremy D.& Schluep, Thomas. 2012. Cyclodextrin-Containing Polymers : Versatile Platforms of Drug Delivery Materials. Journal of Drug Delivery،Vol. 2012, no. 2012, pp.1-17.
https://search.emarefa.net/detail/BIM-458481
Modern Language Association (MLA)
Heidel, Jeremy D.& Schluep, Thomas. Cyclodextrin-Containing Polymers : Versatile Platforms of Drug Delivery Materials. Journal of Drug Delivery No. 2012 (2012), pp.1-17.
https://search.emarefa.net/detail/BIM-458481
American Medical Association (AMA)
Heidel, Jeremy D.& Schluep, Thomas. Cyclodextrin-Containing Polymers : Versatile Platforms of Drug Delivery Materials. Journal of Drug Delivery. 2012. Vol. 2012, no. 2012, pp.1-17.
https://search.emarefa.net/detail/BIM-458481
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-458481