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Potential Survival Benefit of Anti-Apoptosis Protein : Survivin-Derived Peptide Vaccine with and without Interferon Alpha Therapy for Patients with Advanced or Recurrent Urothelial Cancer—Results from Phase I Clinical Trials
Joint Authors
Inoue, Ryuta
Masumori, Naoya
Torigoe, Toshihiko
Nishida, Sachiyo
Kitamura, Hiroshi
Tsukamoto, Taiji
Tanaka, Toshiaki
Sato, Noriyuki
Kawami, Sachiyo
Hirohashi, Yoshihiko
Takahashi-Takaya, Akari
Source
Clinical and Developmental Immunology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-20
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
We previously identified a human leukocyte antigen (HLA)-A24-restricted antigenic peptide, survivin-2B80–88, a member of the inhibitor of apoptosis protein family, recognized by CD8+cytotoxic T lymphocytes (CTL).
In a phase I clinical trial of survivin-2B80-88 vaccination for metastatic urothelial cancer (MUC), we achieved clinical and immunological responses with safety.
Moreover, our previous study indicated that interferon alpha (IFNα) enhanced the effects of the vaccine for colorectal cancer.
Therefore, we started a new phase I clinical trial of survivin-2B80–88 vaccination with IFNα for MUC patients.
Twenty-one patients were enrolled and no severe adverse event was observed.
HLA-A24/survivin-2B80–88 tetramer analysis and ELISPOT assay revealed a significant increase in the frequency of the peptide-specific CTLs after vaccination in nine patients.
Six patients had stable disease.
The effects of IFNα on the vaccination were unclear for MUC.
Throughout two trials, 30 MUO patients received survivin-2B80–88 vaccination.
Patients receiving the vaccination had significantly better overall survival than a comparable control group of MUO patients without vaccination (P=0.0009).
Survivin-2B80–88 vaccination may be a promising therapy for selected patients with MUC refractory to standard chemotherapy.
This trial was registered with UMIN00005859.
American Psychological Association (APA)
Tanaka, Toshiaki& Kitamura, Hiroshi& Inoue, Ryuta& Nishida, Sachiyo& Takahashi-Takaya, Akari& Kawami, Sachiyo…[et al.]. 2013. Potential Survival Benefit of Anti-Apoptosis Protein : Survivin-Derived Peptide Vaccine with and without Interferon Alpha Therapy for Patients with Advanced or Recurrent Urothelial Cancer—Results from Phase I Clinical Trials. Clinical and Developmental Immunology،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-458501
Modern Language Association (MLA)
Tanaka, Toshiaki…[et al.]. Potential Survival Benefit of Anti-Apoptosis Protein : Survivin-Derived Peptide Vaccine with and without Interferon Alpha Therapy for Patients with Advanced or Recurrent Urothelial Cancer—Results from Phase I Clinical Trials. Clinical and Developmental Immunology No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-458501
American Medical Association (AMA)
Tanaka, Toshiaki& Kitamura, Hiroshi& Inoue, Ryuta& Nishida, Sachiyo& Takahashi-Takaya, Akari& Kawami, Sachiyo…[et al.]. Potential Survival Benefit of Anti-Apoptosis Protein : Survivin-Derived Peptide Vaccine with and without Interferon Alpha Therapy for Patients with Advanced or Recurrent Urothelial Cancer—Results from Phase I Clinical Trials. Clinical and Developmental Immunology. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-458501
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-458501