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Metabolomic Analysis of Complex Chinese Remedies : Examples of Induced Nephrotoxicity in the Mouse from a Series of Remedies Containing Aristolochic Acid
Joint Authors
Wei-Chu, Li
Lee, Shoei-Sheng
Chen, Guan-Yuan
Kuo, Ching-Hua
Tsai, I-Lin
Tsai, Dong-Ming
Liao, Hsiao-Wei
Kang, Jaw-Jou
Tseng, Y. Jane
Wang, San-Yuan
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-03-31
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Aristolochic acid nephropathy is caused by aristolochic acid (AA) and AA-containing herbs.
In traditional Chinese medicine, a principle called “Jun-Chen-Zou-Shi” may be utilized to construct a remedial herbal formula that attempts to mitigate the toxicity of the main ingredient.
This study used Bu-Fei-A-Jiao-Tang (BFAJT) to test if the compound remedy based on a principle of “Jun-Chen-Zou-Shi” can decrease the toxicity of AA-containing herbs.
We compared the three toxicities of AA standard, Madouling (an Aristolochia herb), and a herbal formula BFAJT.
AA standard was given for BALB/c mice at a dose of 5 mg/kg bw/day or 7.5 mg/kg bw/day for 10 days.
Madouling and BFAJT were given at an equivalence of AA 0.5 mg/kg bw/day for 21 days.
Nephrotoxicity was evaluated by metabolomics and histopathology.
The urinary metabolomics profiles were characterized by 1H NMR spectroscopy.
The spectral data was analyzed with partial least squares discriminant analysis, and the significant differential metabolites between groups were identified.
The result showed different degrees of acute renal tubular injuries, and metabolomics analysis found that the kidney injuries were focused in proximal renal tubules.
Both metabolomics and pathological studies revealed that AA standard, Madouling, and BFAJT were all nephrotoxicants.
The compositions of the compound remedy did not diminish the nephrotoxicity caused by AA.
American Psychological Association (APA)
Tsai, Dong-Ming& Kang, Jaw-Jou& Lee, Shoei-Sheng& Wang, San-Yuan& Tsai, I-Lin& Chen, Guan-Yuan…[et al.]. 2013. Metabolomic Analysis of Complex Chinese Remedies : Examples of Induced Nephrotoxicity in the Mouse from a Series of Remedies Containing Aristolochic Acid. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-458566
Modern Language Association (MLA)
Tsai, Dong-Ming…[et al.]. Metabolomic Analysis of Complex Chinese Remedies : Examples of Induced Nephrotoxicity in the Mouse from a Series of Remedies Containing Aristolochic Acid. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-458566
American Medical Association (AMA)
Tsai, Dong-Ming& Kang, Jaw-Jou& Lee, Shoei-Sheng& Wang, San-Yuan& Tsai, I-Lin& Chen, Guan-Yuan…[et al.]. Metabolomic Analysis of Complex Chinese Remedies : Examples of Induced Nephrotoxicity in the Mouse from a Series of Remedies Containing Aristolochic Acid. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-458566
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-458566