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Immune Response of Cytotoxic T Lymphocytes and Possibility of Vaccine Development for Hepatitis C Virus Infection
Joint Authors
Hiraide, Ayako
Ishii, Shigeaki
Hiroishi, Kazumasa
Sakaki, Masashi
Eguchi, Junichi
Omori, Risa
Doi, Hiroyoshi
Imawari, Michio
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-05-20
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Immune responses of cytotoxic T lymphocytes (CTLs) are implicated in viral eradication and the pathogenesis of hepatitis C.
Weak CTL response against hepatitis C virus (HCV) may lead to a persistent infection.
HCV infection impairs the function of HCV-specific CTLs; HCV proteins are thought to actively suppress host immune responses, including CTLs.
Induction of a strong HCV-specific CTL response in HCV-infected patients can facilitate complete HCV clearance.
Thus, the development of a vaccine that can induce potent CTL response against HCV is strongly expected.
We investigated HCV-specific CTL responses by enzyme-linked immuno-spot assay and/or synthetic peptides and identified over 40 novel CTL epitopes in the HCV protein.
Our findings may contribute to the development of the HCV vaccine.
In this paper, we describe the CTL responses in HCV infection and the attempts at vaccine development based on recent scientific articles.
American Psychological Association (APA)
Hiroishi, Kazumasa& Eguchi, Junichi& Ishii, Shigeaki& Hiraide, Ayako& Sakaki, Masashi& Doi, Hiroyoshi…[et al.]. 2010. Immune Response of Cytotoxic T Lymphocytes and Possibility of Vaccine Development for Hepatitis C Virus Infection. Journal of Biomedicine and Biotechnology،Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-458571
Modern Language Association (MLA)
Hiroishi, Kazumasa…[et al.]. Immune Response of Cytotoxic T Lymphocytes and Possibility of Vaccine Development for Hepatitis C Virus Infection. Journal of Biomedicine and Biotechnology No. 2010 (2010), pp.1-10.
https://search.emarefa.net/detail/BIM-458571
American Medical Association (AMA)
Hiroishi, Kazumasa& Eguchi, Junichi& Ishii, Shigeaki& Hiraide, Ayako& Sakaki, Masashi& Doi, Hiroyoshi…[et al.]. Immune Response of Cytotoxic T Lymphocytes and Possibility of Vaccine Development for Hepatitis C Virus Infection. Journal of Biomedicine and Biotechnology. 2010. Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-458571
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-458571