Transcranial Magnetic Stimulation Studies in Alzheimer's Disease
Joint Authors
Ferreri, Florinda
Chisari, Carmelo
Del Duca, Marco
Tombini, Mario
Assenza, Federica
Guerra, Andrea
Ursini, Francesca
Vollaro, Stefano
Bressi, Federica
Scrascia, Federica
Trotta, Laura
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-07-06
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Although motor deficits affect patients with Alzheimer's disease (AD) only at later stages, recent studies demonstrated that primary motor cortex is precociously affected by neuronal degeneration.
It is conceivable that neuronal loss is compensated by reorganization of the neural circuitries, thereby maintaining motor performances in daily living.
Effectively several transcranial magnetic stimulation (TMS) studies have demonstrated that cortical excitability is enhanced in AD and primary motor cortex presents functional reorganization.
Although the best hypothesis for the pathogenesis of AD remains the degeneration of cholinergic neurons in specific regions of the basal forebrain, the application of specific TMS protocols pointed out a role of other neurotransmitters.
The present paper provides a perspective of the TMS techniques used to study neurophysiological aspects of AD showing also that, based on different patterns of cortical excitability, TMS may be useful in discriminating between physiological and pathological brain aging at least at the group level.
Moreover repetitive TMS might become useful in the rehabilitation of AD patients.
Finally integrated approaches utilizing TMS together with others neuro-physiological techniques, such as high-density EEG, and structural and functional imaging as well as biological markers are proposed as promising tool for large-scale, low-cost, and noninvasive evaluation of at-risk populations.
American Psychological Association (APA)
Guerra, Andrea& Assenza, Federica& Bressi, Federica& Scrascia, Federica& Del Duca, Marco& Ursini, Francesca…[et al.]. 2011. Transcranial Magnetic Stimulation Studies in Alzheimer's Disease. International Journal of Alzheimer's Disease،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-458573
Modern Language Association (MLA)
Guerra, Andrea…[et al.]. Transcranial Magnetic Stimulation Studies in Alzheimer's Disease. International Journal of Alzheimer's Disease No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-458573
American Medical Association (AMA)
Guerra, Andrea& Assenza, Federica& Bressi, Federica& Scrascia, Federica& Del Duca, Marco& Ursini, Francesca…[et al.]. Transcranial Magnetic Stimulation Studies in Alzheimer's Disease. International Journal of Alzheimer's Disease. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-458573
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-458573