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Treatment with CB2 Agonist JWH-133 Reduces Histological Features Associated with Erectile Dysfunction in Hypercholesterolemic Mice
Joint Authors
Stergiopulos, Nikolaos
Lenglet, Sébastien
Souza dos Santos, Robson Augusto
Savergnini, Silvia Quintao
Montecucco, Fabrizio
Mach, François
Faye, Younouss
Costa-Fraga, Fabiana Pereira
Steffens, Sabine
Fraga-Silva, Rodrigo Araujo
da Silva, Rafaela Fernandes
Source
Clinical and Developmental Immunology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-03
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Hypercholesterolemia is one of the most important risk factors for erectile dysfunction, mostly due to the impairment of oxidative stress and endothelial function in the penis.
The cannabinoid system might regulate peripheral mechanisms of sexual function; however, its role is still poorly understood.
We investigated the effects of CB2 activation on oxidative stress and fibrosis within the corpus cavernosum of hypercholesterolemic mice.
Apolipoprotein-E-knockout mice were fed with a western-type diet for 11 weeks and treated with JWH-133 (selective CB2 agonist) or vehicle during the last 3 weeks.
CB2 receptor expression, total collagen content, and reactive oxygen species (ROS) production within the penis were assessed.
In vitro corpus cavernosum strips preparation was performed to evaluate the nitric oxide (NO) bioavailability.
CB2 protein expression was shown in cavernosal endothelial and smooth muscle cells of wild type and hypercholesterolemic mice.
Treatment with JWH-133 reduced ROS production and NADPH-oxidase expression in hypercholesterolemic mice penis.
Furthermore, JWH-133 increased endothelial NO synthase expression in the corpus cavernosum and augmented NO bioavailability.
The decrease in oxidative stress levels was accompanied with a reduction in corpus cavernosum collagen content.
In summary, CB2 activation decreased histological features, which were associated with erectile dysfunction in hypercholesterolemic mice.
American Psychological Association (APA)
Fraga-Silva, Rodrigo Araujo& Costa-Fraga, Fabiana Pereira& Montecucco, Fabrizio& Faye, Younouss& Savergnini, Silvia Quintao& Lenglet, Sébastien…[et al.]. 2013. Treatment with CB2 Agonist JWH-133 Reduces Histological Features Associated with Erectile Dysfunction in Hypercholesterolemic Mice. Clinical and Developmental Immunology،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-458580
Modern Language Association (MLA)
Fraga-Silva, Rodrigo Araujo…[et al.]. Treatment with CB2 Agonist JWH-133 Reduces Histological Features Associated with Erectile Dysfunction in Hypercholesterolemic Mice. Clinical and Developmental Immunology No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-458580
American Medical Association (AMA)
Fraga-Silva, Rodrigo Araujo& Costa-Fraga, Fabiana Pereira& Montecucco, Fabrizio& Faye, Younouss& Savergnini, Silvia Quintao& Lenglet, Sébastien…[et al.]. Treatment with CB2 Agonist JWH-133 Reduces Histological Features Associated with Erectile Dysfunction in Hypercholesterolemic Mice. Clinical and Developmental Immunology. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-458580
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-458580