Hemodynamics and Mechanobiology of Aortic Valve Inflammation and Calcification
Joint Authors
Balachandran, Kartik
Yoganathan, Ajit P.
Sucosky, Philippe
Source
International Journal of Inflammation
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-07-06
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Cardiac valves function in a mechanically complex environment, opening and closing close to a billion times during the average human lifetime, experiencing transvalvular pressures and pulsatile and oscillatory shear stresses, as well as bending and axial stress.
Although valves were originally thought to be passive pieces of tissue, recent evidence points to an intimate interplay between the hemodynamic environment and biological response of the valve.
Several decades of study have been devoted to understanding these varied mechanical stimuli and how they might induce valve pathology.
Here, we review efforts taken in understanding the valvular response to its mechanical milieu and key insights gained from in vitro and ex vivo whole-tissue studies in the mechanobiology of aortic valve remodeling, inflammation, and calcification.
American Psychological Association (APA)
Balachandran, Kartik& Sucosky, Philippe& Yoganathan, Ajit P.. 2011. Hemodynamics and Mechanobiology of Aortic Valve Inflammation and Calcification. International Journal of Inflammation،Vol. 2011, no. 2011, pp.1-15.
https://search.emarefa.net/detail/BIM-458584
Modern Language Association (MLA)
Balachandran, Kartik…[et al.]. Hemodynamics and Mechanobiology of Aortic Valve Inflammation and Calcification. International Journal of Inflammation No. 2011 (2011), pp.1-15.
https://search.emarefa.net/detail/BIM-458584
American Medical Association (AMA)
Balachandran, Kartik& Sucosky, Philippe& Yoganathan, Ajit P.. Hemodynamics and Mechanobiology of Aortic Valve Inflammation and Calcification. International Journal of Inflammation. 2011. Vol. 2011, no. 2011, pp.1-15.
https://search.emarefa.net/detail/BIM-458584
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-458584