PP13 and PAPP-A in the First and Second Trimesters : Predictive Factors for Preeclampsia?

Abstract EN

Background.

Preeclampsia affects 5-6% of all pregnancies.

Predictive factors of preeclampsia can be helpful in early diagnosis of this disease.

In this study the predictive values of biochemical markers placenta protein 13 (PP13) and pregnancy-associated plasma protein A (PAPP-A) have been assessed in early diagnosis of preeclampsia.

Methods.

This case-control study was conducted on 1500 women who presented to a healthcare center of Sari, Iran, between 2010 and 2011.

Blood samples were drawn in weeks 11–13 and 24–28 of pregnancy.

Of them who developed preeclampsia were considered as case group.

A control group consisted of similar women regarding mean age, body mass index (BMI), and pregnancy age.

PAPP-A and PP13 serum levels were measured.

Data were analyzed using proper statistical tests.

Results.

PAPP-A and PP13 serum levels were significantly lower in both the first and second trimesters in women who developed preeclampsia (P<0.001).

The cumulative value of all four variables with cut-off point of 238.5 has sensitivity, specificity of 91.0%, and undercurve surface of 0.968 which is the most diagnostic value for preeclampsia.

Conclusion.

It is possible to advantage measuring of PAPP-A and PP13 in the first and second trimesters especially their cumulative values in both trimesters for prediction of the incidence of preeclampsia.