PP13 and PAPP-A in the First and Second Trimesters : Predictive Factors for Preeclampsia?
Joint Authors
Naghshvar, Farshad
Ehetshami, Sara
Peyvandi, Sepideh
Moslemi Zadeh, Narges
Gheshlaghi, Parand
Source
ISRN Obstetrics and Gynecology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-18
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
Preeclampsia affects 5-6% of all pregnancies.
Predictive factors of preeclampsia can be helpful in early diagnosis of this disease.
In this study the predictive values of biochemical markers placenta protein 13 (PP13) and pregnancy-associated plasma protein A (PAPP-A) have been assessed in early diagnosis of preeclampsia.
Methods.
This case-control study was conducted on 1500 women who presented to a healthcare center of Sari, Iran, between 2010 and 2011.
Blood samples were drawn in weeks 11–13 and 24–28 of pregnancy.
Of them who developed preeclampsia were considered as case group.
A control group consisted of similar women regarding mean age, body mass index (BMI), and pregnancy age.
PAPP-A and PP13 serum levels were measured.
Data were analyzed using proper statistical tests.
Results.
PAPP-A and PP13 serum levels were significantly lower in both the first and second trimesters in women who developed preeclampsia (P<0.001).
The cumulative value of all four variables with cut-off point of 238.5 has sensitivity, specificity of 91.0%, and undercurve surface of 0.968 which is the most diagnostic value for preeclampsia.
Conclusion.
It is possible to advantage measuring of PAPP-A and PP13 in the first and second trimesters especially their cumulative values in both trimesters for prediction of the incidence of preeclampsia.
American Psychological Association (APA)
Moslemi Zadeh, Narges& Naghshvar, Farshad& Peyvandi, Sepideh& Gheshlaghi, Parand& Ehetshami, Sara. 2012. PP13 and PAPP-A in the First and Second Trimesters : Predictive Factors for Preeclampsia?. ISRN Obstetrics and Gynecology،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-458585
Modern Language Association (MLA)
Moslemi Zadeh, Narges…[et al.]. PP13 and PAPP-A in the First and Second Trimesters : Predictive Factors for Preeclampsia?. ISRN Obstetrics and Gynecology No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-458585
American Medical Association (AMA)
Moslemi Zadeh, Narges& Naghshvar, Farshad& Peyvandi, Sepideh& Gheshlaghi, Parand& Ehetshami, Sara. PP13 and PAPP-A in the First and Second Trimesters : Predictive Factors for Preeclampsia?. ISRN Obstetrics and Gynecology. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-458585
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-458585