Migrating into Genomics with the Neural Crest

Author

Bronner, Marianne E.

Source

Advances in Biology

Issue

Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2014-06-22

Country of Publication

Egypt

No. of Pages

8

Main Subjects

Natural & Life Sciences (Multidisciplinary)
Biology

Abstract EN

Neural crest cells are a fascinating embryonic cell type, unique to vertebrates, which arise within the central nervous system but emigrate soon after its formation and migrate to numerous and sometimes distant locations in the periphery.

Following their migratory phase, they differentiate into diverse derivatives ranging from peripheral neurons and glia to skin melanocytes and craniofacial cartilage and bone.

The molecular underpinnings underlying initial induction of prospective neural crest cells at the neural plate border to their migration and differentiation have been modeled in the form of a putative gene regulatory network.

This review describes experiments performed in my laboratory in the past few years aimed to test and elaborate this gene regulatory network from both an embryonic and evolutionary perspective.

The rapid advances in genomic technology in the last decade have greatly expanded our knowledge of important transcriptional inputs and epigenetic influences on neural crest development.

The results reveal new players and new connections in the neural crest gene regulatory network and suggest that it has an ancient origin at the base of the vertebrate tree.

American Psychological Association (APA)

Bronner, Marianne E.. 2014. Migrating into Genomics with the Neural Crest. Advances in Biology،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-458618

Modern Language Association (MLA)

Bronner, Marianne E.. Migrating into Genomics with the Neural Crest. Advances in Biology No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-458618

American Medical Association (AMA)

Bronner, Marianne E.. Migrating into Genomics with the Neural Crest. Advances in Biology. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-458618

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-458618