![](/images/graphics-bg.png)
Mucin Gene Expression in Reflux Laryngeal Mucosa : Histological and In Situ Hybridization Observations
Joint Authors
Dettmar, Peter W.
Pearson, Jeffrey P.
Bulmer, David M.
Ali, Mahmoud El-Sayed
Source
International Journal of Otolaryngology
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-24
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Objectives/Hypothesis.
To determine if laryngopharyngeal reflux alters mucin gene expression in laryngeal mucosa.
Methods.
In situ hybridization was employed to study the expression of the 8 well-characterised mucin genes MUC1-4, 5AC, 5B, 6, and 7 in reflux laryngeal mucosa from laryngeal ventricles, posterior commissures, and vocal folds compared to control/normal laryngeal mucosa.
Results.
MUC1-5 genes are expressed in normal and reflux laryngeal mucosa.
MUC1, 3 and 4 are expressed in respiratory and squamous mucosa whereas MUC2 and 5AC are expressed in respiratory mucosa only.
MUC3, 4 and 5AC are downregulated in reflux mucosa.
MUC5AC expression is significantly reduced in the 3 mucosal sites and when mucosal type was taken into account, this remains significant in combined laryngeal and ventricular mucosa only.
Conclusions.
MUC3, 4 and 5AC expression is downregulated in laryngopharyngeal reflux.
This may be due to laryngeal mucosal metaplasia and/or alteration of mucin gene expression in the preexisting mucosa.
Altered mucin gene expression might predispose laryngeal mucosa to the damaging effect of reflux.
American Psychological Association (APA)
Ali, Mahmoud El-Sayed& Bulmer, David M.& Dettmar, Peter W.& Pearson, Jeffrey P.. 2014. Mucin Gene Expression in Reflux Laryngeal Mucosa : Histological and In Situ Hybridization Observations. International Journal of Otolaryngology،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-458619
Modern Language Association (MLA)
Ali, Mahmoud El-Sayed…[et al.]. Mucin Gene Expression in Reflux Laryngeal Mucosa : Histological and In Situ Hybridization Observations. International Journal of Otolaryngology No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-458619
American Medical Association (AMA)
Ali, Mahmoud El-Sayed& Bulmer, David M.& Dettmar, Peter W.& Pearson, Jeffrey P.. Mucin Gene Expression in Reflux Laryngeal Mucosa : Histological and In Situ Hybridization Observations. International Journal of Otolaryngology. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-458619
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-458619