Microglia and Macrophages in Malignant Gliomas : Recent Discoveries and Implications for Promising Therapies
Joint Authors
Carvalho da Fonseca, Anna Carolina
Badie, Behnam
Source
Clinical and Developmental Immunology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-25
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Malignant gliomas are the most common primary brain tumors.
Their deadliest manifestation, glioblastoma multiforme (GBM), accounts for 15% of all primary brain tumors and is associated with a median survival of only 15 months even after multimodal therapy.
There is substantial presence of microglia and macrophages within and surrounding brain tumors.
These immune cells acquire an alternatively activated phenotype with potent tumor-tropic functions that contribute to glioma growth and invasion.
In this review, we briefly summarize recent data that has been reported on the interaction of microglia/macrophages with brain tumors and discuss potential application of these findings to the development of future antiglioma therapies.
American Psychological Association (APA)
Carvalho da Fonseca, Anna Carolina& Badie, Behnam. 2013. Microglia and Macrophages in Malignant Gliomas : Recent Discoveries and Implications for Promising Therapies. Clinical and Developmental Immunology،Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-458623
Modern Language Association (MLA)
Carvalho da Fonseca, Anna Carolina& Badie, Behnam. Microglia and Macrophages in Malignant Gliomas : Recent Discoveries and Implications for Promising Therapies. Clinical and Developmental Immunology No. 2013 (2013), pp.1-5.
https://search.emarefa.net/detail/BIM-458623
American Medical Association (AMA)
Carvalho da Fonseca, Anna Carolina& Badie, Behnam. Microglia and Macrophages in Malignant Gliomas : Recent Discoveries and Implications for Promising Therapies. Clinical and Developmental Immunology. 2013. Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-458623
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-458623