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A Bioinformatics Pipeline for the Analyses of Viral Escape Dynamics and Host Immune Responses during an Infection
Joint Authors
Lloyd, Andrew
Leung, Preston
Bull, Rowena
Luciani, Fabio
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-10
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Rapidly mutating viruses, such as hepatitis C virus (HCV) and HIV, have adopted evolutionary strategies that allow escape from the host immune response via genomic mutations.
Recent advances in high-throughput sequencing are reshaping the field of immuno-virology of viral infections, as these allow fast and cheap generation of genomic data.
However, due to the large volumes of data generated, a thorough understanding of the biological and immunological significance of such information is often difficult.
This paper proposes a pipeline that allows visualization and statistical analysis of viral mutations that are associated with immune escape.
Taking next generation sequencing data from longitudinal analysis of HCV viral genomes during a single HCV infection, along with antigen specific T-cell responses detected from the same subject, we demonstrate the applicability of these tools in the context of primary HCV infection.
We provide a statistical and visual explanation of the relationship between cooccurring mutations on the viral genome and the parallel adaptive immune response against HCV.
American Psychological Association (APA)
Leung, Preston& Bull, Rowena& Lloyd, Andrew& Luciani, Fabio. 2014. A Bioinformatics Pipeline for the Analyses of Viral Escape Dynamics and Host Immune Responses during an Infection. BioMed Research International،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-458650
Modern Language Association (MLA)
Leung, Preston…[et al.]. A Bioinformatics Pipeline for the Analyses of Viral Escape Dynamics and Host Immune Responses during an Infection. BioMed Research International No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-458650
American Medical Association (AMA)
Leung, Preston& Bull, Rowena& Lloyd, Andrew& Luciani, Fabio. A Bioinformatics Pipeline for the Analyses of Viral Escape Dynamics and Host Immune Responses during an Infection. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-458650
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-458650