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Association of the Receptor for Advanced Glycation End Products Gene Polymorphisms and Circulating RAGE Levels with Diabetic Retinopathy in the Chinese Population
Joint Authors
Li, Yuan
Sun, Hong
Han, Liyuan
Wu, Qunhong
Hao, Yanhua
Fan, Xiaohong
Cui, Yu
Yang, Li
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-04
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Objectives.
This study investigated the association between polymorphisms in the receptor for advanced glycation end products (RAGE) gene and the susceptibility to diabetic retinopathy (DR) in a Chinese population and identified a correlation between serum-soluble RAGE (sRAGE) levels and DR risk.
Materials and Methods.
We enrolled 1040 patients with type 2 diabetes mellitus: 372 patients with DR and 668 without retinopathy (NDR).
All polymorphisms were genotyped by time-of-flight mass spectrometry.
Serum levels of sRAGE were assayed by enzyme-linked immunosorbent assays.
The interaction of SNPs was analyzed by multifactor dimensionality reduction (MDR).
Results.
The frequency of the SS genotype for the G82S polymorphism was 12.4% in the DR group and 6.6% in the NDR group; this difference was significant.
G82S was associated with sRAGE levels.
Specifically, after adjustments for age, sex, duration, and glucose metabolism, serum sRAGE levels were significantly higher in DR subjects with the S/S genotype than in NDR subjects in general.
In the DR group, subjects with the G/S genotype had lower sRAGE levels than subjects with the G/G or S/S genotype (P<0.01).
The best multilocus genetic interaction model was assessed using the MDR method; 2184A/G, 1704G/T, G82S, and −429T/C were identified.
Conclusions.
The findings suggest that the G82S polymorphism in the RAGE gene is associated with DR risk, and G82S was associated with circulating levels of sRAGE.
The mechanism by which G82S polymorphism modulates the sRAGE levels remains to be elucidated.
American Psychological Association (APA)
Yang, Li& Wu, Qunhong& Li, Yuan& Fan, Xiaohong& Hao, Yanhua& Sun, Hong…[et al.]. 2013. Association of the Receptor for Advanced Glycation End Products Gene Polymorphisms and Circulating RAGE Levels with Diabetic Retinopathy in the Chinese Population. Journal of Diabetes Research،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-458656
Modern Language Association (MLA)
Yang, Li…[et al.]. Association of the Receptor for Advanced Glycation End Products Gene Polymorphisms and Circulating RAGE Levels with Diabetic Retinopathy in the Chinese Population. Journal of Diabetes Research No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-458656
American Medical Association (AMA)
Yang, Li& Wu, Qunhong& Li, Yuan& Fan, Xiaohong& Hao, Yanhua& Sun, Hong…[et al.]. Association of the Receptor for Advanced Glycation End Products Gene Polymorphisms and Circulating RAGE Levels with Diabetic Retinopathy in the Chinese Population. Journal of Diabetes Research. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-458656
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-458656