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Aquaporin-6 Expression in the Cochlear Sensory Epithelium Is Downregulated by Salicylates
Joint Authors
Gastaldi, Giulia
Tritto, Simona
Fontana, Jacopo Maria
Laforenza, Umberto
Masetto, Sergio
Tosco, Marisa
Botta, Laura
Perin, Paola
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-01-12
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
We characterize the expression pattern of aquaporin-6 in the mouse inner ear by RT-PCR and immunohistochemistry.
Our data show that in the inner ear aquaporin-6 is expressed, in both vestibular and acoustic sensory epithelia, by the supporting cells directly contacting hair cells.
In particular, in the Organ of Corti, expression was strongest in Deiters' cells, which provide both a mechanical link between outer hair cells (OHCs) and the Organ of Corti, and an entry point for ion recycle pathways.
Since aquaporin-6 is permeable to both water and anions, these results suggest its possible involvement in regulating OHC motility, directly through modulation of water and chloride flow or by changing mechanical compliance in Deiters' cells.
In further support of this role, treating mice with salicylates, which impair OHC electromotility, dramatically reduced aquaporin-6 expression in the inner ear epithelia but not in control tissues, suggesting a role for this protein in modulating OHCs' responses.
American Psychological Association (APA)
Perin, Paola& Tritto, Simona& Botta, Laura& Fontana, Jacopo Maria& Gastaldi, Giulia& Masetto, Sergio…[et al.]. 2010. Aquaporin-6 Expression in the Cochlear Sensory Epithelium Is Downregulated by Salicylates. Journal of Biomedicine and Biotechnology،Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-458667
Modern Language Association (MLA)
Perin, Paola…[et al.]. Aquaporin-6 Expression in the Cochlear Sensory Epithelium Is Downregulated by Salicylates. Journal of Biomedicine and Biotechnology No. 2010 (2010), pp.1-8.
https://search.emarefa.net/detail/BIM-458667
American Medical Association (AMA)
Perin, Paola& Tritto, Simona& Botta, Laura& Fontana, Jacopo Maria& Gastaldi, Giulia& Masetto, Sergio…[et al.]. Aquaporin-6 Expression in the Cochlear Sensory Epithelium Is Downregulated by Salicylates. Journal of Biomedicine and Biotechnology. 2010. Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-458667
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-458667