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Evaluation of Antileishmanial Activity of Selected Brazilian Plants and Identification of the Active Principles
Joint Authors
Giménez-Turba, Alberto
Niero, Rivaldo
dos Santos Silva, Bruna
Bolda Mariano, Luisa Nathália
Vicente Farias, Ingrid
Malheiros, Angela
Gazoni, Vanessa Fátima
Meyre-Silva, Christiane
Cechinel Filho, Valdir
Gutierrez-Yapu, David
Gomes do Nascimento, Fabiana
Salamanca, Efraín
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-09
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
This study evaluated extracts, fractions, and isolated compounds from some selected Brazilian medicinal plants against strains of promastigotes of Leishmania amazonensis and L.
brasiliensis in vitro.
The cell viability was determined, comparing the results with reference standards.
The dichloromethane fractions of the roots, stems, and leaves of Allamanda schottii showed IC50 values between 14.0 and 2.0 μg/mL.
Plumericin was the main active compound, with IC50 of 0.3 and 0.04 μg/mL against the two species of Leishmania analyzed.
The hexane extract of Eugenia umbelliflora fruits showed IC50 of 14.3 and 5.7 μg/mL against L.
amazonensis and L.
brasiliensis, respectively.
The methanolic extracts of the seeds of Garcinia achachairu and guttiferone A presented IC50 values of 35.9 and 10.4 μg/mL, against L.
amazonensis, respectively.
The ethanolic extracts of the stem barks of Rapanea ferruginea and the isolated compound, myrsinoic acid B, presented activity against L.
brasiliensis with IC50 of 24.1 and 6.1 μg/mL.
Chloroform fraction of Solanum sisymbriifolium exhibited IC50 of 33.8 and 20.5 μg/mL, and cilistol A was the main active principle, with IC50 of 6.6 and 3.1 μg/mL against L.
amazonensis and L.
brasiliensis, respectively.
It is concluded that the analyzed plants are promising as new and effective antiparasitic agents.
American Psychological Association (APA)
Cechinel Filho, Valdir& Meyre-Silva, Christiane& Niero, Rivaldo& Bolda Mariano, Luisa Nathália& Gomes do Nascimento, Fabiana& Vicente Farias, Ingrid…[et al.]. 2013. Evaluation of Antileishmanial Activity of Selected Brazilian Plants and Identification of the Active Principles. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-458698
Modern Language Association (MLA)
Cechinel Filho, Valdir…[et al.]. Evaluation of Antileishmanial Activity of Selected Brazilian Plants and Identification of the Active Principles. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-458698
American Medical Association (AMA)
Cechinel Filho, Valdir& Meyre-Silva, Christiane& Niero, Rivaldo& Bolda Mariano, Luisa Nathália& Gomes do Nascimento, Fabiana& Vicente Farias, Ingrid…[et al.]. Evaluation of Antileishmanial Activity of Selected Brazilian Plants and Identification of the Active Principles. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-458698
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-458698