Tetrandrine Suppresses Cancer Angiogenesis and Metastasis in 4T1 Tumor Bearing Mice
Joint Authors
He, Kai
He, Tong-Chuan
Lv, Gui-Yuan
Ji, Xing
Zhang, Qi
Gao, Jian-Li
Chen, Su-Hong
Zhao, Yan
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-05-25
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Metastasis remains the most deadly aspect of cancer and still evades direct treatment.
Thus, there is a great need to develop new treatment regimens to suppress tumor cells that have escaped surgical removal or that may have already disseminated.
We have found that tetrandrine (TET) exhibits anticolon cancer activity.
Here, we investigate the inhibition effect of TET to breast cancer metastasis, angiogenesis and its molecular basis underlying TET’s anticancer activity.
We compare TET with chemotherapy drug doxorubicin in 4T1 tumor bearing BALB/c mice model and find that TET exhibits an anticancer metastatic and antiangiogenic activities better than those of doxorubicin.
The lung metastatic sites were decreased by TET, which is confirmed by bioluminescence imaging in vivo.
On the other hand, laser doppler perfusion imaging (LDI) was used for measuring the blood flow of tumor in 4T1-tumor bearing mice.
As a result, the local blood perfusion of tumor was markedly decreased by TET after 3 weeks.
Mechanistically, TET treatment leads to a decrease in p-ERK level and an increase in NF-κB levels in HUVECs.
TET also regulated metastatic and angiogenic related proteins, including vascular endothelial growth factor, hypoxia-inducible factor-1α, integrin β5, endothelial cell specific molecule-1, and intercellular adhesion molecule-1 in vivo.
American Psychological Association (APA)
Gao, Jian-Li& Ji, Xing& He, Tong-Chuan& Zhang, Qi& He, Kai& Zhao, Yan…[et al.]. 2013. Tetrandrine Suppresses Cancer Angiogenesis and Metastasis in 4T1 Tumor Bearing Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-458701
Modern Language Association (MLA)
Gao, Jian-Li…[et al.]. Tetrandrine Suppresses Cancer Angiogenesis and Metastasis in 4T1 Tumor Bearing Mice. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-458701
American Medical Association (AMA)
Gao, Jian-Li& Ji, Xing& He, Tong-Chuan& Zhang, Qi& He, Kai& Zhao, Yan…[et al.]. Tetrandrine Suppresses Cancer Angiogenesis and Metastasis in 4T1 Tumor Bearing Mice. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-458701
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-458701