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The Aggregation Inhibitor Peptide QBP1 as a Therapeutic Molecule for the Polyglutamine Neurodegenerative Diseases
Joint Authors
Oishi, Shinya
Popiel, H. Akiko
Fujii, Nobutaka
Strittmatter, Warren J.
Nagai, Yoshitaka
Burke, James R.
Toda, Tatsushi
Takeuchi, Toshihide
Wada, Keiji
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-30
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Misfolding and abnormal aggregation of proteins in the brain are implicated in the pathogenesis of various neurodegenerative diseases including Alzheimer's, Parkinson's, and the polyglutamine (polyQ) diseases.
In the polyQ diseases, an abnormally expanded polyQ stretch triggers misfolding and aggregation of the disease-causing proteins, eventually resulting in neurodegeneration.
In this paper, we introduce our therapeutic strategy against the polyQ diseases using polyQ binding peptide 1 (QBP1), a peptide that we identified by phage display screening.
We showed that QBP1 specifically binds to the expanded polyQ stretch and inhibits its misfolding and aggregation, resulting in suppression of neurodegeneration in cell culture and animal models of the polyQ diseases.
We further demonstrated the potential of protein transduction domains (PTDs) for in vivo delivery of QBP1.
We hope that in the near future, chemical analogues of aggregation inhibitor peptides including QBP1 will be developed against protein misfolding-associated neurodegenerative diseases.
American Psychological Association (APA)
Popiel, H. Akiko& Burke, James R.& Strittmatter, Warren J.& Oishi, Shinya& Fujii, Nobutaka& Takeuchi, Toshihide…[et al.]. 2011. The Aggregation Inhibitor Peptide QBP1 as a Therapeutic Molecule for the Polyglutamine Neurodegenerative Diseases. Journal of Amino Acids،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-458706
Modern Language Association (MLA)
Popiel, H. Akiko…[et al.]. The Aggregation Inhibitor Peptide QBP1 as a Therapeutic Molecule for the Polyglutamine Neurodegenerative Diseases. Journal of Amino Acids No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-458706
American Medical Association (AMA)
Popiel, H. Akiko& Burke, James R.& Strittmatter, Warren J.& Oishi, Shinya& Fujii, Nobutaka& Takeuchi, Toshihide…[et al.]. The Aggregation Inhibitor Peptide QBP1 as a Therapeutic Molecule for the Polyglutamine Neurodegenerative Diseases. Journal of Amino Acids. 2011. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-458706
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-458706